Ceftazidimeに関する基礎的・臨床的研究 FUNDAMENTAL AND CLINICAL EVALUATION OF CEFTAZIDIME

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Abstract

セフェム系抗生物質Ceftazidime (CAZ, SN 401) の抗菌作用, 吸収排泄および臨床成績を検討し, 次の知見を得た。<BR>臨床分離菌336株の感受性を測定したところ, 本剤は<I>P. aeruginosa</I>では72.1%が1.56~6.25μg/mlの範囲にあり, Cefsulodinに等しくCefoperazoneよりも強い抗菌力を示した。<I>S. marceseens</I>では全株が0.39~6.25μg/mlの範囲にあり, Cefoperazone, Cefmetazole, Cefotiamなどよりも著しく優れていた。また, <I>Klebsiella, E. coli, P. mirabilis</I>なども良好な感受性を示した。<BR>妊婦に静注投与したところ, 高い血中濃度が得られ, 尿中排泄 (0~24時間) は85%以上の回収率を示した。また婦人性器内濃度も高く, 骨盤死腔液への移行も比較的良好であった。<BR>子宮内感染, 子宮付属器炎, 骨盤死腔炎, 子宮癌術後尿路感染など22例の産婦人科感染に対し, 本剤1~4g/日, 3~7日間静注投与したところ, 17例に効果を認めた。<BR>副作用や臨床検査値の異常はみられなかつた。

Ceftazidime (CAZ, SN401), a cephem antibiotic, was studied for its antibacterial activity, pharmacokinetic behaviour, and clinical efficacy, and the following results were obtained.<BR>1. Sensitivity distribution of 336 strains of clinical isolates were determined. MICs ranged from 1.56-6.25 μg/ml in 72.1% of strains of <I>P. aeruginosa</I>. This MIC range was similar to that of cefsulodine, and CAZ was more active than cefoperazone. Against <I>S. marcescens</I>, MICs ranged from 0.39 to 6.25μg/ml in all the strains, and CAZ was much more active than cefoperazone, cefmetazole and cefotiam. It also showed satisfactory sensitivity against <I>Klebsiella, E. coil</I> or <I>P. mirabilis</I>.<BR>2. After CAZ was administered intravenously to pregnant women, high blood levels of CAZ were achieved. Urinary recovery rates within 24 hrs were 85% or higher. Also, concentrations of CAZ in genital organs were high and penetration into pelvic cavity fluid was comparatively good.<BR>3. CAZ was administered intravenously at a daily dose of 1-4 g for consecutive 3-7 days to 22 patients with obsterical and gynecological infections, and 17 cases responded well to CAZ. No significant adverse reaction or abnormal laboratory findings were noticed.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 31(Supplement3), 788-801, 1983

    Japanese Society of Chemotherapy

Codes

  • NII Article ID (NAID)
    130004194250
  • NII NACSIS-CAT ID (NCID)
    AN00186653
  • Text Lang
    UNK
  • ISSN
    0009-3165
  • NDL Article ID
    2641578
  • NDL Source Classification
    SC561(産婦人科学)
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-42
  • Data Source
    NDL  J-STAGE 
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