尿路感染症におけるMT-141の基礎的・臨床的検討

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  • BASIC AND CLINICAL STUDIES OF MT-141 IN URINARY TRACT INFECTION

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MICs of MT-141, CMZ and CPZ against each 25 strains of S. epidermidis, S. faecalis, E. coli, C. freundii, K. pneumoniae, Enterobacter, S. marcescens, P. mirabilis, P.vulgaris were measured by agar dilution method with inoculum size of 106 and 108/ml.<BR>Antibacterial activity of MT-141 against gram-positive cocci such as S. epidermidis and S. faecalis seemed to be weaker than other 2 drugs. Peak MIC of the drug against E. coli was 1.56 μg/ml with inoculum size of 108/ml. The result indicated that antibacterial activity of MT-141 was 1 to 2 folds stronger than other 2 drugs.<BR>Poor antibacterial activity of this drug was demonstrated against K. pneumoniae, C. freundii, Enterobacter and S. marcescens except P. mirabilis and P.vulgaris.<BR>Overall clinical efficacy of 1 case of acute simple pyelonephritis was proved moderate. In 21 cases with chronic complicated UTI overall clinical efficacy was 62%; excellent in 2 cases, moderate in 11 cases and poor in 8 cases according to the second edition of criteria for clinical evaluation recommended by Japanese UTI committee.<BR>No subjective and objective adverse effect was seen in any case and clinical laboratory test showed slight eosinophilia in 3 cases, slight rising of Al-P in 2 cases and GPT levels in a case.

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