ACUTE TOXICITY STUDY OF T-2588 IN MICE, RATS AND BEAGLE DOGS

DOI

Bibliographic Information

Other Title
  • T-2588のマウス, ラット, イヌでの急性毒性試験

Abstract

Acute toxicity study of T-2588 was carried out in mice, rats and beagle dogs, and the following results were obtained.<BR>1) In the oral administration, LD50 values were more than 6 g/kg in mice and rats, and more than 2g/kg in beagle dogs.<BR>No hematological and serum biochemical changes were observed in beagle dogs.<BR>2) In the subcutaneous administration, LD50 values were more than 6g/kg in mice and rats. At necropsy, administered test articles were remained in the injected site of mice and rats, and granulation tissue were found in the injected area of mice and rats. Enlargement of cecum lumen was observed in rats.<BR>3) In the intraperitoneal administration, LD50 values were more than 6g/kg in male and 5.86g/kg in female mice, and 5.63g/kg in male and 5.09g/kg in female rats.<BR>At necropsy, inflammatory adhesion of abdominal organs were observed in mice and rats.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 34 (Supplement2), 166-172, 1986

    Japanese Society of Chemotherapy

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