高齢者におけるCarumonamの臨床的検討

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タイトル別名
  • CARUMONAM IN ELDERLY SUBJECTS

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Carumonam, a new monobactam antibiotic, was administered to 25 elderly patients with infections and its clinical efficacy and side effects were investigated. The diagnoses were respiratory tract infection in 22 patients (pneumonia, 16; lower respiratory infection, 6), urinary tract infection in 2 patients, and fever of unknown origin in 1 patient. The treatment was “effective” in 11 cases, “slightly effective” in 10, and “ineffective” in 4; the efficacy rate (including “slightly effective” and “effective”) being 84%. Bacteriologically, out of 4 strains of Pseudomonas aeruginosa, two were eradicated, one decreased and one remained unchanged. Two strains of Klebsiella pneumoniae and one strain each of Proteus mirabilis, Serratia marcescens, and Escherichia coli were also eradicated, one strain of Pseudomonas cepacia was substituted by Enterococcus faecalis, and two strains of Staphylococcus aureus emerged after treatment. As to side effects, exanthema was found in one patient. Abnormal laboratory findings were leukocytopenia in 2 cases, an increase in eosinophils in 1 case, and elevated GPT and ALP in 1 case. Remission and recovery were, however, invariably obtained after discontinuation of treatment. We, therefore, think that if used in infections caused by susceptible bacteria, carumonam is also a useful antibiotic for adminisration to elderly patients.

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