β‐Ｌａｃｔａｍ系抗生剤のｓｕｂ‐ＭＩＣに関する研究　ＩＩＩ　　高齢者血清中での抗菌作用

DOI

書誌事項

タイトル別名
  • Studies on the sub-mic of .BETA.-lactam antibiotics. III. Bactericidal activity in elderly serum.
  • III. BACTERICIDAL ACTIVITY IN ELDERLY SERUM
  • (第3報) 高齢者血清中での抗菌作用

抄録

We studied the activity of beta-lactam antibiotics at a sub-minimum inhibitory concentration (sub-MIC) in elderly serum. Mixtures containing serum (60 μl), antibiotic solution (10 μl) and bacterial suspen-sion (10 μl) were incubated for 4 h at 37°C. The colony forming unit (CFU) was determined toevaluate bactericidal activity. Bactericidal activity in elderly serum was similar to that in normalserum against Proteus mirabilis T-250, Pseudomonas aeruginosa and Staphylococcus aureus. However, stronger bactericidal activity against P. mirabilis T-277 and weaker against Escherichia coli and Kleb-siellapneumoniae were observed in elderly serum. Bactericidal activity in elderly serum was Iheat-labile, and lysozyme was thought to play some role in its augmentation.<BR>Piperacillin, cefoperazone and cefbuperazone showed bactericidal or bacteriostatic activity in nutrientbroth, normal serum and elderly serum at a concentration of 1/4 MIC. While carbenicillin, cefazolinand cefmetazole slightly inhibit ed the growth of bacteria in nutrient broth, they showed hardly anybactericidal activity in normal and elderly serum.

収録刊行物

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詳細情報 詳細情報について

  • CRID
    1390001206277661440
  • NII論文ID
    130004195865
  • DOI
    10.11250/chemotherapy1953.36.294
  • ISSN
    18845894
    00093165
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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