内科領域におけるCefpiromeの基礎的, 臨床的検討

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  • BILIARY CONCENTRATION AND CLINICAL EVALUATION OF CEFPIROME. A NEW PARENTERAL CEPHALOSPORIN, IN ELDERLY PATIENTS

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We evaluated the bile excretion and clinical efficacy of cefpirome (CPR), a new parenteral cephalosporin, in elderly patients.<BR>Serial bile samples were collected after 1 g i. v. 60-min infusion or an i.v bolus injection of CPR to patients undergoing PTCD. Peak bile concentrations were 2.65-18.1 μg/ml in two patients with obstructive jaundice.<BR>A clinical evaluation was carried out in 8 patients (pneumonia 3 cases, bronchopneumonia 1, acute bronchitis 1, peritonitis 1, cholangitis 1, pyelonephritis 1). Clinical response was excellent in 2, good in 2, fair in 1 and poor in 2 cases Satisfactory response was obtained in 3 of 5 patients with respiratory tract infection.<BR>No adverse reactions or abnormal laboratory findings were observed except minor leukopenia in one patient.

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