Cefpiromeの基礎的, 臨床的検討

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  • LABORATORY AND CLINICAL STUDIES ON CEFPIROME

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We performed laboratory and clinical studies on cefpirome (CPR), a new cephem antibiotic, with the following results.<BR>We investigated the pharmacokinetics of the drug in nine patients with renal failure after intravenous administration of 1g. The mean plasma concentration of CPR, administered over 5 min, with and without hemodialysis, was 101.6 and 103.9μg/ml. The mean values of T1/2 (β) in plasma were 4.5 and 19.8 h, and tht. AUCs were 287 and 1762μgh/ml.<BR>The clinical efficacy of CPR was studied in 10 patients: 7 with pneumonia, and 1 each with chronic bronchitis, acute pyelitis and acute pyelonephritis, 2 with mycoplasma pneumonia and 1 with rheumatic pneumonia having been excluded as unevaluable.<BR>The clinical response was excellent in 5 cases, good in 4 and fair in 1, with an overall efficacy rate of 90.0%.<BR>Bacteriologically, all causative pathogens were eradicated.<BR>No side-effects were noted, though abnormal laboratory findings were observed in two patients.

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