外科感染症におけるFK037の体内動態と臨床効果

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  • Pharmacokinetics and clinical effects of FK037 in patients with surgical infections

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The kinetic profile of FK037, a new cephem antibiotic, which is highly active antimicrobial agent against Gram-positive bacteria including Staphylococcus aureus and Gram-negative bacteria including Pseudomonas aeruginosa was clarified and its clinical efficacy on biliary tract infections, peritonitis and periproctal abscess was investigated.<BR>1) When 1 g of FK037 was intravenously given to patients who were planned to undergo cholecystectomy, the peak level in the gallbladder tissue was 29.5μg/g and that in the gallbladder bile was 14.5μg/ml at 1 hour after administration.<BR>2) The bile concentration was determined in 6 patients with a drainage tube showing the peak level of 2.79-10.6μg/ml, at 2-3.5 hours after administration at a dose of 1 g. In the case of renal failure it kept high level.<BR>3) The concentration in ascitic fluid in a patient with gastric cancer undergoing abdominal drainage showed peak level of 13.0-30.1μg/ml at 2-3.7 hours after administration at a dose of 1 g.<BR>4) The clinical efficacy was excellent in 4 and good in 4 cases. The isolated organisms were S.aureus in 3, Escherichia coli in 3, P.aeruginosa in 1 and Bacteroides fragilis in 1 case. All these organisms but B. fragilis were sensitive to FK037 and eradicated. Abnormal laboratory data consisted of only slight elevation of serum GPT in 1 case.<BR>It concluded that FK037 is a useful antibiotic agent for treatment of surgical infections.

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