イヌ急性虚血小腸病変の内視鏡的及び病理組織学的検討
書誌事項
- タイトル別名
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- ENDOSCOPIC AND PATHOLOGIC STUDY OF ACUTE SMALL INTESTINAL ISCHEMIA IN MONGREL DOGS
- MEASUREMENT OF INTESTINAL BLOOD FLOW BY LASER DOPPLER FLOWMETRY
- ―小腸組織血流量計測も含めて―
抄録
The small intestinal mucosa of acute ischemic models in the dog was observed endoscopically, taking biopsy specimens and measuring tissue blood flow, in order to determine the relationship between the duration of ischemia and the severity of tissue injury. The mucosal changes observed in the early course of ischemia consisted of longitudinal redness and erosion on the opposite side of mesentery. These changes appeared 30 min after anterior mesenteric artery occlusion. Histological examination revealed that these changes were deprivation at the tip of the villi and congestion of mucosal layer. The mucosal ischemic changes became circumferential 3 to 5 hours following arterial occlusion. The mucosa had a dark red color, along with severe erosion and bleeding at 7 hours or more. Histologically the tissue injury was characterized by coagulation necrosis and infiltration of neutrophils. The rate of tissue blood flow recovery was significantly lower upon reperfusion after 7 and 10 hours of ischemia than after 3 and 5 hours. The ischemic changes were severe in many models after reperfusion. The findings suggest that reperfusion is deterious to the ischemic mucosa. Briefly, based on the pathological findings obtained at various periods after ischemia, it may be concluded that tissue injury and the recovery of tissue blood flow after reperfusion characteristically varied with the duration of ischemia.
収録刊行物
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- 日本消化器内視鏡学会雑誌
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日本消化器内視鏡学会雑誌 36 (5), 927-938_1, 1994
一般社団法人 日本消化器内視鏡学会
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詳細情報 詳細情報について
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- CRID
- 1390282679195846400
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- NII論文ID
- 130004253648
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- ISSN
- 18845738
- 03871207
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可