血管壁よりの prostacycline (PGI<sub>2</sub>) 放出に関する検討 Studies on the release of prostacyclin (PGI<sub>2</sub>) from the vessel walls

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Abstract

Prostacyclin (PGI<sub>2</sub>) is an unstable potent inhibitor of platelet aggregation and is generated by the vessel walls. We examined the effect of platelet antiaggregating agents and calcium antagonists on the release of PGI<sub>2</sub> from rat's thoracic aorta.<br>Each agent was given intraperitoneally to the rat at a dose of 5mg and the rat aorta was incubated with these test agents in the concentration of 0.5mg/ml as in vitro experiment. PGI<sub>2</sub> was measured by the inhibitory effect of ADP-induced human platelet aggregation.<br>The release of PGI<sub>2</sub> from the rat aorta was accelerated by these agents both in vivo and in vitro. Although the release of PGI<sub>2</sub> was inhibited when incubated with hydrocortisone (10mg/ml) and the test agents, this release was more accelerated when incubated with hydrocortisone mixed with the test agents and exogenous arachidonic acid (50μg/ml) than that incubated with hydrocortisone and exogenous arachidonic acid alone.<br>As hydrocortisone is reported to be an inhibitor of phospholipase A<sub>2</sub>, it is assumed that these agents affect the arachidonic acid metabolic pathway following the stage of phospholipase A<sub>2</sub>.

Journal

  • Blood & Vessel

    Blood & Vessel 11(3), 442-445, 1980

    The Japanese Society on Thrombosis and Hemostasis

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