副作用文献情報モニタリングに関する検討

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タイトル別名
  • Study on literature monitoring of adverse drug reactions (ADR).

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In order to grasp the current status of collecting the articles for literature monitoring of adverse drug reactions (ADR) in DI room and to utilize it as a guide for future activities, we investigated the contents and source of the articles which we ourselves selected, collected and reported in monthly drug information journal of our hospital during the period of 1980-1985. We also analysed the contents and source jounals of the articles describing on ADR which had been collected in our DI room during the past 6 years paying our attention to the drugs most frequently reported in the literatures in 1984, and compared with the results of on-line search using MEDLINE to examine the coverage.<BR>The selecting standard of the articles describing on ADR has been established in our DI room. The articles describing on the terms manifesting ADR symptoms as well as drug name or drug group name in the titles of the articles in particular case reports of ADR are indispensable.<BR>From the analysis of the articles collected according to this selecting standard, it was found that the drug groups most frequently reported in the literatures were 1) central nervous system agents, 2) cardiovascular agents, 3) hormone preparations, 4) antineoplastic agents and 5) antibiotic preparations, and this order showed an almost same tendency through the past 5 years. However, individual drug names most frequently reported in the literatures brought about considerable changes every year. According to the source journals reporting ADR, the four journals, “Lancet”, “Brit. Med. J.”, “J. Am. Med. Assoc.” and “N. Engl. J. Med.” were overwhelming, but Japanese journals reporting ADR were widely distributed without focusing on certain journal.<BR>From the study on the coverage, it was found that the number of articles we collected was apparently less than that of MEDLINE, but we had collected the articles describing on important ADR. This study suggests that the literature monitoring of ADR in DI room will play an important role in early collection and early communication of ADR.

収録刊行物

  • 病院薬学

    病院薬学 13 (3), 172-178, 1987

    一般社団法人 日本医療薬学会

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