胆石を有する腸チフス, パラチフスB無症候排菌者を中心とした症例並びに腸チフスに対するcefbtaxime及びその他の抗生物質の効果 Effectiveness of Cefotaxime and other Antibiotics to the Typhoid and Paratyphoid B Carriers with Gall Stones and Typhoid Fever
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The result of medications given to 8 cases of typhoid carrier, 2 cases of paratyphoid carrier and 2 cases of typhoid fever has been reported. All cases of carrier were female, and age distribution ranged from 41 years to 84 years. Gall stones were demonstrated in 6 cases of typhoid carrier and paratyphoid carrier.<BR>Ampicillin, chloramphenicol, nalidixic acid and tetracycline were given to the carriers singly or by combined use of two of these antibiotics, but the administration of each drug failed in eradication of the bacilli.<BR>Cholecystectomy was performed on one case each of typhoid carrier and paratyphoid B carrier. Following the operation, ampicillin was effectively administered in eradication of the bacilli.<BR>Cefotaxime was given to 7 of remaining 8 carriers, and the administration succeeded in eradication of the microbe in 6 cases. The daily dosis was 3.0 to 4.0 g, and 1.0 g was given intramusculary each time. The period of administration was 7 to 14 days. The one case in which failure in eradication of the bacilli was noted in paratyphoid carrier.<BR>Cefotaxime was given to two cases of typhoid fever. In one case, ampicillin seemed to be more effective than cefotaxime, but in another case, cefotaxime proved to be effective.<BR>Antimicrobial activity of cefotaxime was very strong to the isolated Salmonellae as compared with ampicillin, chloramphenicol and cefazolin. The MICs of cefotaxime to the microbe were less than 0.05 μ/ml in inoculum size of 10<SUP>6</SUP>.<BR>Severe adverse reaction of cefotaxime was not observed.
- Kansenshogaku Zasshi
Kansenshogaku Zasshi 54(3), 109-116, 1980
The Japanese Association for Infectious Diseases