Comparative Study of BRL28500 (Clavulanic Acid-Ticarcilin) and Piperacillin in the Treatment of Respiratory Tract Infections
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- MIKI Fumio
- Department of Internal Medicine, Tane General Hospital
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- IKUNO Yoshiyasu
- Department of Internal Medicine, Tane General Hospital
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- INOUE Eiji
- Department of Internal Medicine, Tane General Hospital
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- MURATA Akihito
- Department of Internal Medicine, Tane General Hospital
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- TANIZAWA Shinichi
- Department of Internal Medicine, Tane General Hospital
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- SAKAMOTO Kazuo
- Department of Internal Medicine, Tane General Hospital
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- TAHARA Akira
- Department of Internal Medicine, Tane General Hospital
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- SAITO Akira
- The Second Departmet of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
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- TAMIZAWA Masumi
- The Second Departmet of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
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- HIRAGA Yohmei
- Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
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- KIKUCHI Kohki
- Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
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- YAMAMOTO Tomoko
- Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
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- TAKABE Kazuo
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- NAKAMURA Teruo
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- MIYAZAWA Tadashi
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- TAMURA Toyokazu
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- ENDO Katsumi
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- YONEDA Masashi
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- IDO Yasuo
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- UEHARA Osamu
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- OKAMOTO Katsuhiro
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- SAGARA Morio
- The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
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- TAKISHIMA Tamotsu
- The First Department of Internal Medicine, Tohoku University, School of Medicine
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- IDA Shiro
- The First Department of Internal Medicine, Tohoku University, School of Medicine
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- KONNO Kiyoshi
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- OIZUMI Kotaro
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- AONUMA Seiichi
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- WATANABE Akira
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- SATO Kazuo
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- HAYASHI Izumi
- Department of Respiratory Disease, Iwaki Kyoritsu General Hospital
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- KATSU Masataka
- Department of Internal Medicine, Kasumigaura National Hospital
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- OKUI Shinji
- Department of Internal Medicine, Kasumigaura National Hospital
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- KAWAI Mieko
- Department of Internal Medicine, Kasumigaura National Hospital
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- FUKUI Toshio
- Department of Internal Medicine, Kasumigaura National Hospital
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- ARAKAWA Masaaki
- The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
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- WADA Koichi
- The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
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- MORIMOTO Takao
- The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
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- KABASAWA Tomoko
- The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
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- TAKEDA Hajimu
- Department of Internal Medicine, Nagaoka Red Cross Hospital
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- SEKINE Osamu
- Department of Internal Medicine, Shinrakuen Hospital
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- USUDA Yoshimaru
- Department of Internal Medicine, Shinrakuen Hospital
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- AOKI Nobuki
- Department of Internal Medicine, Shinrakuen Hospital
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- MIYAHARA Tadashi
- The Second Department of Internal Medicine, The Jikei University, School of Medicine
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- SAITO Atsushi
- The Second Department of Internal Medicine, The Jikei University, School of Medicine
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- SHIMADA Jingoro
- The Second Department of Internal Medicine, The Jikei University, School of Medicine
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- SHIBA Kohya
- The Second Department of Internal Medicine, The Jikei University, School of Medicine
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- IKEMOTO Hideo
- Department of Internal Medicine, Juntendo University, School of Medicine
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- WATANABE Kazuyoshi
- Department of Internal Medicine, Juntendo University, School of Medicine
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- KOBAYASHI Hiroyuki
- The First Department of Internal Medicine, Kyorin University, School of Medicine
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- TAKAMURA Kenji
- The First Department of Internal Medicine, Kyorin University, School of Medicine
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- YOSHIDA Masahiko
- The First Department of Internal Medicine, Kyorin University, School of Medicine
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- MASHIMO Keimei
- Department of Internal Medicine, Tokyo Koseinenkin Hospital
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- YAMANE Yoshiji
- Department of Internal Medicine, Tokyo Koseinenkin Hospital
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- TOMI Toshiharu
- Department of Internal Medicine, Tokyo Koseinenkin Hospital
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- KABE Junzaburo
- Department of Chest Medicine, National Medical Center Hospital
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- ISHIBASHI Hiroyoshi
- Department of Chest Medicine, National Medical Center Hospital
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- KUDO Koichiro
- Department of Chest Medicine, National Medical Center Hospital
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- OTA Takeshi
- Department of Chest Medicine, National Medical Center Hospital
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- TANIMOTO Hiroichi
- Department of Respiratory Disease, Toranomon Hospital
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- NAKATANI Ryuo
- Department of Respiratory Disease, Toranomon Hospital
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- YOSHIMURA Kunihiko
- Department of Respiratory Disease, Toranomon Hospital
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- NAKAMORI Yoshitaka
- Department of Respiratory Disease, Toranomon Hospital
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- CHONABAYASHI Naohiko
- Department of Respiratory Disease, Toranomon Hospital
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- NAKATA Koichiro
- Department of Respiratory Disease, Toranomon Hospital
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- WATANABE Kentaro
- Department of Internal Medicine, Tokyo Kyosai Hospital
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- KOYAMA Masaru
- Department of Internal Medicine, Tokyo Kyosai Hospital
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- IIJIMA Fukuo
- Department of Internal Medicine, Tokyo Kyosai Hospital
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- INAMATSU Takashi
- Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
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- URAYAMA Kyoko
- Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
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- AZUMA Fuyuhiko
- Department of Internal Medicine, Tokyo Denryoku Hospital
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- FUNATSU Yuzo
- Department of Internal Medicine, Tokyo Denryoku Hospital
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- FUJIMORI Ippei
- Department of Internal Medicine, Kawasaki Municipal Hospital
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- KOBAYASHI Yoshio
- Department of Internal Medicine, Kawasaki Municipal Hospital
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- ADACHI Masanori
- Department of Internal Medicine, Kawasaki Municipal Hospital
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- FUKAYA Kazufuto
- The First Department of Internal Medicine, Yokohama City University, School of Medicine
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- OKUBO Takao
- The First Department of Internal Medicine, Yokohama City University, School of Medicine
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- ITO Akira
- The First Department of Internal Medicine, Yokohama City University, School of Medicine
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- MATSUMOTO Hiroshi
- The First Department of Internal Medicine, Yokohama City University, School of Medicine
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- SUZUKI Junichi
- The First Department of Internal Medicine, Yokohama City University, School of Medicine
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- YOSHIIKE Yasuhiro
- The First Department of Internal Medicine, Yokohama City University, School of Medicine
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- WATANUKI Yuji
- Department of Internal Medicine, Yokohama Teishin Hospital
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- ODAGIRI Shigeki
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- CHIBA Jun
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- SUZUKI Kaneo
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- MUROHASHI Koou
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- FUKUDA Tsutomu
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- KIUCHI Mitsuyo
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- ASHIKARI Yasuhiko
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- SHIMOKATA Kaoru
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- YOSHII Saiji
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- TAKANOU Osamu
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- SAKAI Shuzo
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- NISHIWAKI Keisuke
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- TAKEURA Shigeki
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- KISHIMOTO Hirotsugu
- The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
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- SATAKE Tatsuo
- The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
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- TAKAGI Kenzo
- The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
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- YAMAKI Kenichi
- The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
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- SASAMOTO Motohide
- The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
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- SASAKI Tomoyasu
- The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
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- TAKEUCHI Toshihiko
- The First Department of Internal Medicine, Nagoya City University, School of Medicine
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- KATO Masahito
- The First Department of Internal Medicine, Nagoya City University, School of Medicine
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- KATO Joichi
- The First Department of Internal Medicine, Nagoya City University, School of Medicine
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- ITO Goh
- The First Department of Internal Medicine, Nagoya City University, School of Medicine
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- YAMAMOTO Toshiyuki
- Department of Internal Medicine, Nagoyashi Koseiin Hospital
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- SUZUKI Kanzo
- Department of Internal Medicine, Nagoyashi Koseiin Hospital
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- YAMAMOTO Kazuhide
- Department of Internal Medicine, Nagoyashi Koseiin Hospital
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- ADACHI Satoru
- Department of Internal Medicine, Nagoyashi Koseiin Hospital
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- OYAMA Kaoru
- Department of Internal Medicine, Toyama Prefectural central Hospital
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- SUZUKI Kunikazu
- Department of Internal Medicine, Toyama Prefectural central Hospital
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- OTANI Nobuo
- Department of Respiratory Disease, Kanazawa Medical College
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- HAYASE Mitsuru
- Department of Respiratory Disease, Kanazawa Medical College
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- KUZE Fumiyuki
- The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
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- TSUJINO Hiroyuki
- The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
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- INABA Nobuo
- The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
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- IKEDA Nobuaki
- The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
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- MATSUBARA Tsuneo
- The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
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- USHIDA Shinichi
- The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
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- AMITANI Ryoichi
- Department of Internal Medicine, Takeda General Hospital
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- NAKANISHI Michiyasu
- Department of Internal Medicine, Takeda General Hospital
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- OKUBO Hiroshi
- Department of Internal Medicine, Rakusai New Town Hospital, Kansai Medical University
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- UEDA Yoshihiro
- Department of Internal Medicine, Rakusai New Town Hospital, Kansai Medical University
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- NARITA Nobuhiro
- The Second Department of Internal Medicine, Nara Medical College
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- SAWAKI Masayoshi
- The Second Department of Internal Medicine, Nara Medical College
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- MIKASA Keiichi
- The Second Department of Internal Medicine, Nara Medical College
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- YASUNAGA Kojiro
- The First Department of Internal Medicine, Kansai Medical University
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- YONETSU Seibun
- The First Department of Internal Medicine, Kansai Medical University
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- IIDA Yube
- The First Department of Internal Medicine, Kansai Medical University
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- SAKAKIBARA Yoshihiko
- The First Department of Internal Medicine, Kansai Medical University
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- TSUBURA Eiroh
- The First Department of Internal Medicine, Kansai Medical University
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- HAMADA Tomoo
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- FUKUYAMA Koichi
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- FUKUOKA Masahiro
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- ITO Masami
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- HIRAO Fumio
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- KOMATSU Takashi
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- MAEKAWA Nobuo
- Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
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- NISHIYAMA Hideki
- Department of Internal Medicine, Wakayama Red Cross Hospital
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- SUZUKI Yujiro
- Department of Internal Medicine, Wakayama Red Cross Hospital
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- HORIKAWA Sadao
- Department of Internal Medicine, Wakayama Red Cross Hospital
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- TAMURA Masakazu
- Department of Internal Medicine, Wakayama Red Cross Hospital
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- SOEJIMA Rinzo
- The Third Department of Internal Medicine, Tokushima University, School of Medicine
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- NIKI Yoshihito
- Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
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- ADACHI Michifumi
- Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
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- NAKAGAWA Yoshihisa
- Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
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- SUMI Masaru
- Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
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- KURIMURA Osamu
- Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
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- SASAKI Hideyo
- Department of Internal Medicine, Kure National Hospital
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- FUKUHARA Hirofumi
- Department of Internal Medicine, Kure National Hospital
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- MORIMOTO Tadao
- Department of Internal Medicine, Kure National Hospital
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- SAWAE Yoshiro
- The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
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- OKADA Kaoru
- The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
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- KUMAGAI Yukio
- The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
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- SHIGEMATSU Nobuaki
- Research Institute for Disease of the Chest, Faculty of Medicine, Kyushu University
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- AIZAWA Hisamichi
- Research Institute for Disease of the Chest, Faculty of Medicine, Kyushu University
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- TAKII Masahide
- The Second Department of Internal Medicine, Fukuoka University, School of Medicine and Related Hospital
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- OHDO Takafumi
- The Second Department of Internal Medicine, Fukuoka University, School of Medicine and Related Hospital
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- SHINAGAWA Tomoaki
- The Second Department of Internal Medicine, Fukuoka University, School of Medicine and Related Hospital
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- HARA Kohei
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- HIROTA Masaki
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- YAMAGUCHI Keizo
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- KOHNO Shigeru
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- KAGA Hironobu
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- WATANABE Koichi
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- FUJITA Kiyo
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- UEDA Yasuko
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- KOHNO Kota
- The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
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- MATSUMOTO Keizo
- Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
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- NAGATAKE Tsuyoshi
- Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
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- RIKITOMI Naoto
- Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
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- NASU Masaru
- The Second Department of Internal Medicine, Medical College of Oita
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- GOTO Jun
- The Second Department of Internal Medicine, Medical College of Oita
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- GOTO Yoichiro
- The Second Department of Internal Medicine, Medical College of Oita
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- SHIGENO Hideaki
- The Second Department of Internal Medicine, Medical College of Oita
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- TASHIRO Takayoshi
- The Second Department of Internal Medicine, Medical College of Oita
Bibliographic Information
- Other Title
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- 呼吸器感染症に対するBRL28500 (Clavulanic acid-Ticarcillin) とPiperacillinの薬効比較試験成績
- コキュウキ カンセンショウ ニ タイスル BRL 28500 Clavulan
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Abstract
A well-controlled comparative study was undertaken to assess the clinical efficacy and safety of BRL28500 (BRL), a formulation comprising one part of clavulanic acid and 15 parts of ticarcillin, using piperacillin (PIPC) as a reference drug in patients with respiratory tract infections (RTI).<BR>Patients with apparent clinical signs and symptoms of chronic RTI (chronic bronchitis, diffuse panbronchiolitis, infected bronchiectasis, infected pulmonary emphysema, infected pulmonary fibrosis and infected bronchial asthma), acute exacerbation of chronic RTI, bacterial pneumonia and lung abscess were administered 1.6 g of BRL (1.5 g of ticarcillin plus 0.1 g of clavulanic acid) or 2.0 g of PIPC twice daily by intravenous drip infusion for 14 days in principle.<BR>BRL-treated group and PIPC-treated group were compared in terms of clinical efficacy, improvement of clinical symptoms and signs, bacteriological response, incidence of side effects, abnormal changes in laboratory findings and utility. The following results were obtained:<BR>1. BRL and TIPC were administered to a total of 314 patients (BRL to 161 and PIPC to 153). Clinical efficacy was judged in 269 patients (138 on BRL and 131 on PIPC) excluding 45 patients from total patients by the committee.<BR>Incidence of side effects was evaluated in 293 patients (148 on BRL and 145 on PIPC) and abnormal changes in laboratory findings were asessed in 286 patients (141 on BRL and 145 on PIPC).<BR>2. Clinical efficacy rate for the BRL group and PIPC group was 78.8% and 79.4% in total cases, 82.1% (79 patients) and 79.5% (73 patients) in pneumonia and lung abscess and 74.6% (59 patients) and 79.3% (58 patients) in chronic RTI respectively. There was no statistically significant difference between the two groups.<BR>3. As to improvement of clinical symptoms and signs, improvement of ESR in the BRL group was better than that in the PIPC group on 14th day after administration in patients with pneumonia or lung abscess. On the contrary, improvement of rale, WBC and CRP in the BRL group was inferior to those in the PIPC group on 3rd day after administration in patients with chronic RTI. Significant differences were shown in these items between both groups.<BR>4. Bacteriological response was evaluated in 125 patients (68 on BRL and 57 on PIPC) and eradication of causative organisms was 75.0% for the BRL group and 71.9% for the PIPC group, giving no statistical difference between both groups. However, there was a significant difference in preference for BRL to PIPC in terms of eradication of Klebsiella spp. (87.5% for BRL and 16.7% for PIPC).<BR>When causative organisms were classified into two groups according to susceptibility to PIPC, eradication effect of PIPC (94.7%) was superior (p<0.10) to that of BRL (69.6%) in PIPC-sensitive organisms having 50μg/ml of MIC. On the other hand, in PICP-resistant organisms having 50μg/ml of MIC BRL exerted better eradication effect (66.7%) than PIPC (12.5%) and a significant difference was shown between the two groups.<BR>5. In 293 patients assessed incidence of side effects, five patients treated with BRL and eleven patients treated with PIPC complained of side effects and there was no significant difference between both groups.<BR>6. Abnormal changes in laboratory findings were evaluated in 286 patients. Numbers of patients with the abnormal changes were 45 (31.9%) out of 141 patients treated with BRL and 28 (19.3%) out of 145 patients treated with PIPC respectively and the difference was significant (p<0.05) between both groups. Itemized analysis showed that abnormal changes in GPT were found in 26 (18.6%) out to 140 patients treated with BRL and 14 (10.0%) out of 140 patients treated with PIPC and indicated that elevation of BUN were shown only in the PIPC group (4/127, 3.1%), giving tendency of significant difference (p<0.10) on the above items between the two groups.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 61 (8), 914-943, 1987
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390282680024504960
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- NII Article ID
- 130004329310
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 3160447
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- PubMed
- 3125284
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed