Study on Azithromycin in Treatment of Diffuse Panbronchiolitis

• KOBAYASHI Hiroyuki

  First Department of Internal Medicine, Kyorin University School of Medicine

• TAKEDA Hiroaki

  First Department of Internal Medicine, Kyorin University School of Medicine

• SAKAYORI Susumu

  First Department of Internal Medicine, Kyorin University School of Medicine

• KAWAKAMI Yoshikazu

  First Department of Medicine, Hokkaido University, School of Medicine

• OTSUKA Yoshinori

  First Department of Medicine, Hokkaido University, School of Medicine

• TAMURA Masashi

  Third Department of Internal Medicine, Iwate Medical University

• KONISHI Kazuki

  Third Department of Internal Medicine, Iwate Medical University

• TANIMOTO Shinichi

  Department of Internal Medicine, IV, The Jikei University School of Medicine

• FUKAKUSA Motonori

  Department of Internal Medicine, IV, The Jikei University School of Medicine

• SHIMADA Kaoru

  Department of Infectious Diseases, Institute of Medical Science, The University of Tokyo

• SANO Yasuyuki

  Division of Allergy and Respiratory Diseases, Doai Memorial Hospital

• ARAI Yasuo

  Division of Allergy and Respiratory Diseases, Doai Memorial Hospital

• SHISHIDO Harumi

  Department of Respiratory Diseases, Tokyo National Chest Hospital

• WATANABE Hisashi

  Department of Respiratory Diseases, Tokyo National Chest Hospital

• SAKAMOTO Eriko

  Department of Respiratory Diseases, Tokyo National Chest Hospital

• NAKATA Koichiro

  Department of Respiratory Diseases, Toranomon Hospital

• NAKATANI Tatsuo

  Department of Respiratory Diseases, Toranomon Hospital

• TSUBOI Nagayasu

  Department of Respiratory Diseases, Toranomon Hospital

• ODAGIRI Shigeki

  Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center

• SUZUKI Kaneo

  Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center

• YOSHIIKE Yasuhiro

  Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center

• HIRAI Yoshihiro

  Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center

• OKUBO Takao

  First Department of Internal Medicine, Yokohama City University School of Medicine

• IKEDA Hirotada

  First Department of Internal Medicine, Yokohama City University School of Medicine

• ARAKAWA Masaaki

  The Second Department of Internal Medicine, Niigata University, School of Medicine

• WADA Kouichi

  The Second Department of Internal Medicine, Niigata University, School of Medicine

• TSUKADA Hiroki

  The Second Department of Internal Medicine, Niigata University, School of Medicine

• SATO Atsuhiko

  Second Deprtment of Internal Medicine, Hamamatsu University School of Medicine

• CHIDA Kingo

  Second Deprtment of Internal Medicine, Hamamatsu University School of Medicine

• NARITA Nobuhiro

  Second Department of Internal Medicine, Nara Medical University

• SAWAKI Masayoshi

  Second Department of Internal Medicine, Nara Medical University

• MIKASA Keiichi

  Second Department of Internal Medicine, Nara Medical University

• SOEJIMA Rinzo

  Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School

• NIKI Yoshihito

  Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School

• OKIMOTO Niro

  Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School

• SASAKI Takao

  Third Department of Internal Medicine, School of Medicine, Tottori University

• MATSUMOTO Yukio

  Third Department of Internal Medicine, School of Medicine, Tottori University

• SUGIMOTO Yuji

  Third Department of Internal Medicine, School of Medicine, Tottori University

• KIDO Masamitsu

  Department of Respiratory Diseases, University of Occupational and Environmental Health

• NIKAIDO Yoshihiko

  Department of Respiratory Diseases, University of Occupational and Environmental Health

• ARAKAWA Kikuo

  Second Department of Internal Medicine, School of Medicine Fukuoka University

• KOHNO Kenji

  Second Department of Internal Medicine, School of Medicine Fukuoka University

• ISHIBASHI Tsuneo

  Department of Internal Medicine, National Sanatorium Ohmuta Hospital

• TAKAMOTO Masahiro

  Department of Internal Medicine, National Sanatorium Ohmuta Hospital

• KITAHARA Yoshinari

  Department of Internal Medicine, National Sanatorium Ohmuta Hospital

• HARA Kohei

  The Second Department of Internal Medicine, Nagasaki University School of Medicine

• KOHNO Shigeru

  The Second Department of Internal Medicine, Nagasaki University School of Medicine

• KADOTA Junichi

  The Second Department of Internal Medicine, Nagasaki University School of Medicine

• NASU Masaru

  Second Department of Internal Medicine, Oita Medical University

• GOTO Yoichiro

  Second Department of Internal Medicine, Oita Medical University

• YAMASAKI Tohru

  Second Department of Internal Medicine, Oita Medical University

• SAITO Atsushi

  First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

• FUKUHARA Hiroshi

  First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

• INADOME Jun

  First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

Bibliographic Information

Other Title

• びまん性汎細気管支炎に対するazithromycinの臨床的検討
• ビマンセイ ハン サイ キカンシエン ニ タイスル azithromycin

Abstract

In the treatment of diffuse panbronchiolitis, azithromycin (AZM), a new macrolide antibiotic with 15-membred lactone ring, was studied for its efficacy and safety.<BR>AZM, 250 mg, was intermittently administered to a total of 60 patients twice a weeks, for 3 months as a rule, and its efficacy was clinically evaluated in 52 patients and the safety in 55.<BR>The rate of efficacy was 84.6%(44/52). Clinical findings 12 weeks after the start of administration showed a decrease in sputum volume in 30 of 46 patients and amelioration of dyspnea on exertion in 23 of 46 patients, and no worsening of symptoms was observed in the patients. Vital capacity (4/22), FEVi.o (6/21), cold agglutination reaction (22/28), and CRP (16/36) were also improved. The rate of eradication of organisms isolated from the sputum except for indigenous organisms was 39.5%(15/38); 4 of the 22 strains of Pseudomonas aeruginosa were eradicated.<BR>Adverse reactions were observed in 4 of the 55 patients (7.3%), 1 patient each with rash, itching, diarrhea, and a gastric symptom (heavy feeling in the stomach). 4 of the 54 patients (7.4%) exhibited abnormal changes in clinical laboratory test values. These were an increase in eosinophil count in 2, elevation of GOT in 1, and elevation of Al-P in 1. These adverse reactions and abnormal changes in laboratory test values were mild or moderate.<BR>Therefore, long-term intermittent administration of AZM, twice a week, is expected to have the same effect in the treatment of diffuse panbronchiolitis as long-term small-dose administration of 14-membered macrolides such as erythromcin and clarithromycin, whose effects have already been established.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 69 (6), 711-722, 1995

  The Japanese Association for Infectious Diseases

Keywords

• azithromycin
• diffuse panbronchiolitis
• longterm chemotherapy

Details

• CRID: 1390001205047184896
• NII Article ID: 10008726515
• NII Article ID: 130004330374
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.69.711
• COI: 1:STN:280:DyaK2MzktFSksw%3D%3D
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 3618913
• PubMed: 7616016
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3618913
• Web Site: https://search.jamas.or.jp/link/ui/1996009012
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed