Profiles of Intracellular Expression, Distribution, and Activation of Phospholipase A<SUB>2</SUB> in Host Macrophages Infected with <I>Mycobacterium avium</I> complex
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- SANO Chiaki
- Department of Microbiology and Immunology Department of Oto -Rhino-Laryngology, Shimane University School of Medicine
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- SHIMIZU Toshiaki
- Department of Microbiology and Immunology
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- TATANO Yutaka
- Department of Microbiology and Immunology
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- YASUMOTO Ko
- Department of Microbiology and Immunology
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- TOMIOKA Haruaki
- Department of Microbiology and Immunology
Bibliographic Information
- Other Title
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- <I>Mycobacterium avium</I> complex感染マクロファージにおけるフォスフォリパーゼA<SUB>2</SUB>の細胞内動態
- Mycobacterium avium complex感染マクロファージにおけるフォスフォリパーゼA2の細胞内動態
- Mycobacterium avium complex カンセン マクロファージ ニ オケル フォスフォリパーゼ A2 ノ サイボウナイ ドウタイ
- Profiles of Intracellular Expression, Distribution, and Activation of Phospholipase A2 in Host Macrophages Infected with Mycobacterium avium complex
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Abstract
Our recent studies have shown that type IV cytosolic phospholipase A2 (cPLA2) plays an important role in the expression of macrophage (MΦ) antimicrobial activity against the Mycobacterium avium complex (MAC). To clarify the modes of c PLA2 participation in MΦ anti-MAC antimicrobial function in detail, we studied intracellular profiles of phospholilase A2, focusing on c PLA2, in MAC-infected MΦs, with the following findings: In murine peritoneal MΦs, cPLA2 was constitutively expressed even in uninfected MΦs, and MAC infection did not increase intramacrophage c PLA2 expression. In an RAW264.7 mouse MΦ cell line (RAW264.7 MΦs) infected with MAC, a portion of intracellular c PLA2 was concentrated in MAC organisms residing within MΦ phagosomes. MAC infection upregulated intramacrophage c PLA2 expression and induced its phosphorylation. These findings suggest that MAC infection of RAW264.7 MΦs may induce the activation of intracellular c PLA2, translocating it to phagosomes engulfing infected MAC organisms.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 81 (6), 695-699, 2007
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390282680026221440
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- NII Article ID
- 10020105809
- 130004331409
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- NII Book ID
- AN00047715
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- COI
- 1:STN:280:DC%2BD2sjlslOitQ%3D%3D
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- ISSN
- 1884569X
- 03875911
- http://id.crossref.org/issn/03875911
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- NDL BIB ID
- 9301744
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed