口腔粘膜へん平苔せん（ＯＬＰ）の病因に関する研究　発症誘因としての歯科用金属の関与について

DOI

書誌事項

タイトル別名
  • A Study of the Pathogenesis in Oral Lichen Planus: with Reference to Dental Metals.
  • 発症誘因としての歯科用金属の関与について

抄録

Allergic response to the dental prosthetic metals has been considered to be one of the causative factors of oral lichen planus (OLP), however, no evidence has been reported. Therefore, we performed the following experiments in order to clarify the participation of the dental prosthetic metals to immunological mechanism in the development of OLP:<BR>(1) skin patch tests of dental metals, <BR>(2) analyses of the components in the dental prosthetic metals by X-ray microanalysis, and<BR>(3) analyses of the elemental metals localized in the mucosal lesions of OLP by X-ray microanalysis.<BR>In the present study, we found the following evidences:<BR>(1) in OLP patients (31 cases), the same elemental metals showing a positive response to the skin patch tests (21 cases) were significantly detected in each prosthesis (7 cases), (2) inOLPmucosallesions, the same elemental metals (Co) were located in the lysozome of keratinocytes which expressed HLADR antigen (1 case), and (3) HLA-DR positive dendritic cells were observed adjacent to the keratinocytes.<BR>Based on these findings, it was reasonable to be consider that metal ions which were derived from the dental prosthetic metals accumulated in the lysozome of keratinocytes, and keratinocytes and dendritic cells as antigen presenting cells (APC) were related to the allergic response to the dental metals.<BR>These results strongly suggest that the dental metals is a causative factor of OLP.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282681412936064
  • NII論文ID
    130004335419
  • DOI
    10.11277/stomatology1952.42.527
  • ISSN
    21850461
    00290297
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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