肉芽腫性口唇炎５例の臨床病理学的検討 [in Japanese] Cheilitis Granulomatosa. Report of 5 Cases.:Report of 5 Case s [in Japanese]
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Cheilitis granulomatosa (CG) is a rare disease characterized clinically by chronic enlargement of the lips and histologically by nonspecific inflammation and local granulomas with hyperplasia of eptitheloid cells. In this report, five cases with CG, four male and one female, aged between 19 and 47 yrs, with mean age of 30.2 years were presented. Lesions were revealed in the upper lip of two cases and the lower lip of three cases. One of five cases was found to be suffering from Melkersson-Rosenthal syndrome with fissured tongue and oral mucosal swelling, but no peripheral facial nerve palsy. All of the cases had poor oral hygiene, decayed teeth, and periodontitis.<BR>Histological examination revealed edematous change and granulomas of nodularly formed epitheloid cells and proliferation of collagen fibers in the submucosal and muscle layers.<BR>Local treatment was performed by oral hygience, periodontitis therapy, extraction of severely decayed teeth, and apicoectomy. General treatment was performed by the administration of steroids, antiallergic drugs, and antibiotics. As the treatment progressed, the size of lip returned to near normal without recurrence in three cases. In the other two cases, surgical reduction cheiloplasty was performed due to persistent lip swelling and the result was considered to be satisfactory.
- Journal of The Japanese Stomatological Society
Journal of The Japanese Stomatological Society 47(1), 56-60, 1998
Japanese Stomatological Society