生体肝移植後,免疫抑制剤の長期服用患者の口腔内所見  [in Japanese] Intraoral Findings in Liver Transplant Recipents Receiving Immunosuppresive Agents.  [in Japanese]

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Author(s)

    • 山村 功 YAMAMURA Isao
    • 京都大学大学院医学研究科, 感覚運動系病態学講座口腔機能病熊学分野 Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University
    • 青井 陽子 AOI Yoko
    • 京都大学大学院医学研究科, 感覚運動系病態学講座口腔機能病熊学分野 Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University
    • 高橋 克 TAKAHASHI Katsu
    • 京都大学大学院医学研究科, 感覚運動系病態学講座口腔機能病熊学分野 Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University
    • 坪井 陽一 TUBOI Yoichi
    • 京都大学大学院医学研究科, 感覚運動系病態学講座口腔機能病熊学分野 Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University
    • 村上 賢一郎 MURAKAMI Kenichiro
    • 京都大学大学院医学研究科, 感覚運動系病態学講座口腔機能病熊学分野 Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University
    • 飯塚 忠彦 IIZUKA Tadahiko
    • 京都大学大学院医学研究科, 感覚運動系病態学講座口腔機能病熊学分野 Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University

Abstract

Recently organ transplantations have been done in many hospitals in Japan. However, the dentists have no guidelines for dental management of the posttransplant patients receiving immunosuppresive agents.<BR>In this report, the intraoral findings of 10 long-term survivors of liver transplantation for biliary atresia are presented. The mean age was 8.5 years. There was about 2.5-fold higher incidence of dental caries of deciduous teeth in the patients compared to the average of the Japanese. Nevertheless the patients seem not to be susceptible to severe gingivitis. Cyclosporininduced hyperplasia was recognized in one of two patients treated by cyclosporin therapy, but there was no gingival hyperplasia in the tacrolimus group. In addition, the patients showed no disorder in teeth eruption but tended to demonstrate malocclusion such as Angle class III, crowding in the upper dental arch or open bite. The findings suggest that a liver transplant recipient receiving immunosuppresive agents for a long time could be at risk for various dental problems and oral disease.

Journal

  • Journal of The Japanese Stomatological Society

    Journal of The Japanese Stomatological Society 51(2), 137-142, 2002

    Japanese Stomatological Society

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