ショ糖負荷後の耐糖能および尿中Ｃ‐ペプチド値に及ぼす難消化性デキストリンの影響

DOI 被引用文献7件
  • 植田 由香
    松谷化学工業 (株) 研究所生理機能研究室
  • 若林 茂
    松谷化学工業 (株) 研究所生理機能研究室 兵庫医科大学臨床病理学
  • 松岡 瑛
    兵庫医科大学臨床病理学

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タイトル別名
  • Effects of Indigestible Dextrin on Blood Glucose and Urine C-peptide Levels Following Sucrose Loading.

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The effectiveness of an indigestible dextrin (Pine fibre-C®: PF-C) on blood glucose (BG) levels and 2-hour urine C-peptide immunoreactivity (U-CPR) levels following a sucrose load were investigated in healthy human subjects.<BR>1) In order to estimate an effective dose of PF-C for a reduction in BG and U-CPR levels following a 30 g sucrose load, an oral sucrose tolerance test was conducted in 6 male subjects. The percent increase in BG levels following a sucrose load (av. 154%) was reduced by PF-C, 3 and 6g (av. 141% each). Furthermore U-CPR levels were reduced to 86% by addition of PF-C 6g as compared to the sucrose load (4.62±0.72 μg/2hr). The intensity of reduction in U-CPR levels by PF-C, 3 and 30 g were less than that by PF-C 6g. Our results show that the most effective dose of PF-C for a reduction in BG and U-CPR levels is 6 g to sucrose 30 g.<BR>2) To evaluate the effectiveness of a PF-C-supplemented meal on a reduction in U-CPR levels, another sucrose tolerance test was conducted in 35 subjects (male 31, female 4) with a soft adzuki-bean jelly (Mizuyoukan) as a high sucrose (30 g) meal. The percentage of reduction of U-CPR levels in each sex were found to be significant in both the PF-C 3 g-(av. male 85%, female 88%) and 6 g-supplemented meals (av. male 80%, female 64%) as compared to the PF-C-free meal. In addition, in the male subjects, significant relation were found among the percentage of reduction in U-CPR by PF-C, the waist to hip ratio, and the levels of serum total cholesterol, triglyceride and γ-GTP. These results suggest that PF-C is effective for the improvement of hyperinsulinemia in obesity.

収録刊行物

  • 糖尿病

    糖尿病 36 (9), 715-723, 1993

    一般社団法人 日本糖尿病学会

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