書誌事項
- タイトル別名
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- FK506-Induced Diabetes Mellitus in Two Patients Receiving Allogenic Bone Marrow Transplantation.
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We experienced two patients who received allogenic bone marrow transplantation which induced diabetes mellitus (D.M.) following treatment with FK 506. In case 1, after three-week oral adminis trarionof FK 506 for chronic graft-versus-host disease (GVHD), the fasting blood sugar (FBS) level increased from 90 mg/dl to 156 mg/dl, and the C-peptide immunoreactivity (CPR) in the urine was concomitantly decreased to 9.7μg/day. At that time, the FK 506 concentration in the blood was 10 to 15ng/ml. Along with the reduction of the dose of FK 506, the CPR in the urine increased to 47.3yg/day. In case 2, after three-week intravenous administration of FK 506 for chronic GVHD, the FBS level increased from 80 mg/dl to 254 mg/dl and the urine CPR decreased from 256μg/day to 21.6μg/day. At that time, the FK 506 concentration was 15 to 20 ng/ml. Two weeks after readministration of CsA, the FBS level became 84 mg/dl. These findings indicate that D.M. is inducible in a dose-dependent manner in patients receiving a therapeutic dose of FK 506, while the FK 506-induced D. M. can be reversed by the reduction and/or discontinuation of the administra tionof FK 506.
収録刊行物
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- 糖尿病
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糖尿病 41 (2), 137-142, 1998
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679880903040
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- NII論文ID
- 130004338443
- 10005566659
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可