気管支喘息患児末梢血単核細胞からの Interleukin 1 (IL 1) 産生について

DOI

書誌事項

タイトル別名
  • PRODUCTION OF INTERLEUKIN 1 (IL1) FROM MONONUCLEAR CELLS STIMULATED WITH FETAL CALF SERUM, MITE ANTIGEN AND LIPOPOLYSACCARIDE-COMPARISON BETWEEN ASTHMATIC CHILDREN AND HEALTHY INDIVIDUALS
  • ダニ抗原, ウシ胎児血清, リポ多糖体添加の効果

抄録

Interleukin 1 (IL1) production by peripheral blood mononuclear cells (MNC) from asthmatic children and healthy individuals was studied. IL1 production was observed, when MNC were cultured in the medium supplemented with fetal calf serum, but not when cultured with human serum of AB blood type. IL1 production in this condition was more prominent in asthmatic children than in healthy controls. This suggested that asthmatic children had more T cells sensitized to the antigens contained in FCS than the controls. When MNC were stimulated with Dermatophagoides farinae (Df) or lipopolysaccharide (LPS) in the medium with serum of AB blood type, IL1 production was induced in both the patients and the controls in the same degree. More IL1 was produced by MNC cultured with FCS in stimulaion with Df or LPS. These observations suggest that LPS and Df have shown the effect as nonspecific activators rather than as antigens.<br>Induction of IL1 production from MNC by stimulation with calf serum acting as an antigen and with mite preparation acting as an nonspecific activator or antigen suggested that in volvement of IL1 induced by such mechanism in the inflamatory reaction in allergy.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390001204475184000
  • NII論文ID
    130004370846
  • DOI
    10.3388/jspaci.4.63
  • ISSN
    18822738
    09142649
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ