食物依存性運動誘発性アナフィラキシーの4例

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  • FOUR CASES OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS

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We reported on four children with food-dependent exercise-induced anaphylaxis. They were one boy and three girls, and the age of onset ranged 13 to 16 years. The causative foods were shellfish in two cases, wheat and potato in one case, and wheat only in another. Their symptoms were urticaria, dyspnea and unconsciousness. The exercise related to the symptoms were running, volleyball and walking at a quick pace. The intervals between meal and exercise ranged 10 minutes to 2 hours. Specific IgE antibodies to the causative foods were detected in all cases. All cases performed exercise challenge test. The exercise did not induce any symptoms. The skin wheal to compound 48/80 after the exercise seemed to be larger than that before the exercise in all cases except Case 2. These results suggest that type I allergic reaction relates to these symptoms, and change of mast cell releasability by exercise may be involved in the development of these symptoms.

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