BASIC AND CLINICAL STUDIES ON CEFOTIAM FOR THE INFECTIOUS DISEASES IN THE OTORHINOLARYNGOLOGICAL FIELD

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  • FURUTA SHIGERU
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • OBATA ETSURO
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • HANAMURE YUTAKA
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • FUKUDA KATSUNORI
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • FUKAMI KOZO
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University
  • OHYAMA MASARU
    Department of Otorhinolaryngology, School of Medicine, Kagoshima University

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Other Title
  • 耳鼻咽喉科領域感染症に対するCefotiamの基礎的, 臨床的研究
  • ジビ インコウカ リョウイキ カンセンショウ ニ タイスル Cefotiam

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Abstract

Basic and clinical studies on cefotiam (CTM) for the infectious diseases in otorhinolaryngological field were performed and the following results were obtained.<BR>1. The peak value in the serum level of CTM was 18.05μg/ml by 0.5g administration and 35.2μg/ml by 1g at 30 minutes after a single intravenous injection. CTM was rapidly excreted from the blood after injection and was detected a little amount in serum at 6 hours after the administration.<BR>2. Tissue concentrations of the drug into palatine tonsil and the mucous membrane of the nasal cavity or maxillary sinus were seen in relatively rapid and good manner.<BR>3. Chemotherapeutic results excepting Pseudomonas aeruginosa infections (3 cases) were excellent in 2 cases, good in 7 cases and poor in 3 cases of 12 patients with the infectious diseases in otorhinolaryngological field.<BR>4. No adverse effects and abnormal values in the laboratory findings were revealed in every patients.

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