急性中耳炎および急性扁桃炎に対するBacampicillinの薬効評価:Amoxycillinとの二重盲検比較試験による検討 [in Japanese] Double-Blind Trial of Bacampicillin in the Treatment of Acute Suppurative Otitis media and Acute Tonsillitis [in Japanese]
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In acute suppurative otitis media and acute tonsillitis (including peritonsillitis and peritonsillar abscess), efficacy, safety and usefulness of bacampicillin (BAPC) were compared with those of amoxycillin (AMPC), as a standard drug, by a double blind controlled study. The following results were obtained;<BR>1) The global improvement rating (GIR) judged by doctors in acute suppurative otitis media showed no significant difference between both groups, but BAPC was superior to AMPC in acute tonsillitis (P<0.05).<BR>2) No significant difference was observed in the incidence of side effects between both groups.<BR>3) BAPC was superior to AMPC in regard to the global utility rating judged by doctors and evaluation committee in acute tonsillitis (P<0.05), although there was no significant difference between both groups in acute suppurative otitis media.<BR>As mentioned above, BAPC was superior to AMPC in regard to GIR in acute tonsillitis and GIR in single infections of β-strept. in the disease However, there was no significant difference between both groups in not only GIR in acute suppurative otitis media but also sensitivity of β-strept. to ABPC (active compound of BAPC) and AMPC.
- OTOLOGIA FUKUOKA
OTOLOGIA FUKUOKA 25(5), 1398-1414, 1979
JIBI TO RINSHO KAI