ハウスダスト鼻アレルギーに対する減感作療法の長期継続例の検討  [in Japanese] Long-term effects of immunotherapy on perennial nasal allergy  [in Japanese]

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Abstract

ハウスダスト鼻アレルギーにおける減感作療法の長期継続例について検討し以下の結果を得た. 1. 症状スコアでは季節変動を思わせる観察月での差はなかつた. 2. 重症度において一時改善は2ヵ月以内に53.4%, 1年以内に93.2%, 2年以内に96.1%, 安定改善は2ヵ月以内に23.3%, 1年以内に49.5%, 2年以内に64.1%, 安定軽症化は2 カ月以内に9.7%, 1年以内に31.1%, 2年以内に43.7%にみられた. 一時改善の時期が早いほど安定改善が得られやすい結果であつた. 3. 症状スコアは減感作療法開始後 2, 3ヵ月で改善しており, 以後ほとんど変化がなかつた. 一時改善の時期が遅い群では維時量決定時に鼻閉スコアの低下が小さかつた. 鼻誘発テストのスコア改善は症状に比べて遅く, 維持量決定時以降も低下の傾向は続くが, 必ずしも症状の経過と一致しなかつた. 4. 13歳から15歳が自然治癒を期待できる年代と考えられた.

Immunotherapy using house dust extracts was administered over a 2 year period to 103 patients with perennial nasal allergy. With the immunotherapy, symptoms improved within 2 months in 23% of the patients. 50% responded within 1 year and 64% within 2 years. In patients who showed a rapid improvement, the subsequent course was better than in those responding more slowly to treatment. In patients whose nasal obstruction failed to improve, the subsequent course was even less favorable than those who responded somewhat to treatment. The severity of reaction to the nasal provocation test with house dust extracts decreased gradually. However, the response to the test and the severity of clinical symptoms did not always correspond with each other.

Journal

  • OTOLOGIA FUKUOKA

    OTOLOGIA FUKUOKA 36(5Supplement6), 1105-1110, 1990

    JIBI TO RINSHO KAI

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