耳鼻咽喉科のいわゆる自律神経失調症症例に対するalprazolamの使用経験 The clinical efficacy of alprazolam in cervial dizziness and abnormal sensations in the throat and tinnitus

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耳鼻咽喉科領域におけるいわゆる自律神経失調症である頸性めまい症14名, 咽喉頭異常感症16名, 老人性難聴に伴う耳鳴症19名計49名にalprazolamを基礎とした併用療法を行いその有効性を検討した. いずれも不定愁訴が多く心理的要因の関与が強いと考えられた症例であり, 頸性めまい症ではtizanidine, tofisopam, 咽喉頭異常感症では半夏厚朴湯, 耳鳴症ではmethycobalaminを併用した. 各疾患における有効率は頸性めまい症93%, 咽喉頭異常感症56%, 耳鳴症32%で, これらを総合した有効率は57%であった. 副作用は眠気を6名 (12%) に認めたが, alprazolamを1日0.4mg (就寝前服用) に減量し日中の眠気は消失した. alprazolamの使用にあたつては眠気の副作用に注意する必要があるが, 末梢前庭障害や小脳脳幹障害が否定された頸部交感神経が関係する頸性めまい症と老人性難聴に伴う耳鳴症にalprazolamを基礎とした併用療法は有効であると考えられた.

Combinations of alprazolam and other drugs were given to 49 patients with so-called autonomic imbalance in the field of otolaryngology-14 with cervical dizziness, 16 with abnormal sensations in the throat, and 19 with tinnitus associated with presbycusis- to assess the effectiveness. of the drugs. All cases had a number of indefinite complaints seemed to be strongly influenced by psychogenic factors. The drugs used in combination with alprazolam were tizanidine and tofisopam in the cases of cervical dizziness,“Hange-Koboku-to” in the cases of abnormal sensations the throat, and methycobalamin in the cases of tinnitus. Clinical efficacy was noted in 93% of the cAses with cervial dizziness, in 56% of the cases with sensations in the throat, and in 32% of those with tinnitus. The average overall efficacy rate was 57%. Regarding side effects, daytime drowsiness was reported by six patients(12%), but it disapperared following a decrease in the dose of alprazolam to 0.4mg/day (taken at bedtime). Although caution should be used against the side effects of drowsiness when using alprazolam, the results showed that alprazolam in the above combination therapy was effective in the treatment of cervical dizziness and tinnitus associated with presbycusis.

収録刊行物

  • 耳鼻と臨床

    耳鼻と臨床 40(2), 220-224, 1994

    耳鼻

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