鼻科用Fosfomycin (FOM) の副鼻腔炎に対するネブライザー療法による用量設定比較試験

DOI
  • 馬場 駿吉
    Department of Otorhinolaryngology, Medical School, Nagoya City University
  • 宮本 直哉
    Department of Otorhinolaryngology, Medical School, Nagoya City University
  • 小松崎 篤
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, School of Medicine
  • 三宅 浩郷
    Department of Otorhinolaryngology, Tokyo Hospital, School of Medicine, Tokai University
  • 斎藤 等
    Department of Otorhinolaryngology, Fukui Medical School
  • 藤枝 重治
    Department of Otorhinolaryngology, Fukui Medical School
  • 高波 二三
    Department of Otorhinolaryngology, Fukui General Hospital
  • 小林 武弘
    Department of Otorhinolaryngology, Kasugai City Hospital
  • 横田 明
    Department of Otorhinolaryngology, Nagoya City Higashi General Hospital
  • 板谷 知巳
    Department of Otorhinolaryngology, Kainan Hospital
  • 西村 忠郎
    Department of Otorhinolaryngology, Fujita Health University, Banbuntane Hotokukai Hospital
  • 徳田 寿一
    Department of Otorhinolaryngology, Fujita Health University, Banbuntane Hotokukai Hospital
  • 森島 夏樹
    Department of Otorhinolaryngology, Fujita Health University, Banbuntane Hotokukai Hospital
  • 中村 晴彦
    Department of Otorhinolaryngology, Tounou hospital
  • 坂倉 康夫
    Department of Otolaryngology, Medical School, Mie University
  • 間島 雄一
    Department of Otolaryngology, Medical School, Mie University
  • 湯田 厚司
    Department of Otolaryngology, Medical School, Mie University
  • 浜口 幸吉
    Department of Otorhinolaryngology, Yokkaichi City Hospital
  • 坂倉 健二
    Department of Otorhinolaryngology, Yamamoto General Hospital
  • 斎田 哲
    Department of Otorhinolaryngology, Suzuka Central General Hospital
  • 村上 泰
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
  • 竹中 洋
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
  • 水越 文和
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
  • 西山 彰子
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
  • 伊達 敬一
    Department of Otorhinolaryngology, Kyoto Saiseikai Hospital
  • 福島 龍之
    Department of Otorhinolaryngology, Kyoto Saiseikai Hospital
  • 園田 隆郎
    Department of Otorhinolaryngology, Ohtsu City Hospital
  • 大島 渉
    Department of Otorhinolaryngology, Kyoto Second Red Cross Hospital
  • 日向 誠
    Department of Otorhinolaryngology, Kyoto Second Red Cross Hospital
  • 寺薗 富朗
    Department of Otorhinolaryngology, Kyoto Second Red Cross Hospital
  • 山下 敏夫
    Department of Otorhinolaryngology, Kansai Medical University
  • 牛呂 公一
    Department of Otorhinolaryngology, Kansai Medical University
  • 佐藤 一雄
    Department of Otorhinolaryngology, Kansai Medical University
  • 井野 千代徳
    Department of Otorhinolaryngology, Kori Hospital, Kansai Medical University
  • 松永 喬
    Department of Otorhinolaryngology, Nara Medical University
  • 矢形 礼貴
    Department of Otorhinolaryngology, Nara Medical University
  • 和久田 幸之助
    Department of Otorhinolaryngology, Nara Prefectural Nara Hospital
  • 太田 和博
    Department of Otorhinolaryngology, Nara Prefectural Mimuro Hospital
  • 吉川 恒男
    Department of Otorhinolaryngology, Nara Prefectural Gojo Hospital
  • 柏木 令子
    Department of Otorhinolaryngology, Saiseikai Chuwa Hospital
  • 前田 稔彦
    Department of Otorhinolaryngology, Saiseikai Chuwa Hospital
  • 衛藤 幸男
    Department of Otorhinolaryngology, Saiseikai Nara Hospital
  • 田中 真理子
    Department of Otorhinolaryngology, Saiseikai Nara Hospital
  • 秋岡 勝哉
    Department of Otorhinolaryngology, Haibara General Hospital
  • 横田 雅子
    Department of Otorhinolaryngology, Tenri City Hospital
  • 松永 亨
    Department of Otorhinolaryngology, Medical School, Osaka University
  • 久保 武
    Department of Otorhinolaryngology, Medical School, Osaka University
  • 川嵜 良明
    Department of Otorhinolaryngology, Medical School, Osaka University
  • 浅井 英世
    Department of Otorhinolaryngology, Suita City Hospital
  • 神畠 俊子
    Department of Otorhinolaryngology, Suita City Hospital
  • 芦田 健太郎
    Department of Otorhinolaryngology, Kawanishi City Hospital
  • 中井 義明
    Department of Otorhinolaryngology, Osaka City University, Medical School
  • 大橋 淑宏
    Department of Otorhinolaryngology, Osaka City University, Medical School
  • 杉浦 欣一
    Department of Otorhinolaryngology, Osaka City University, Medical School
  • 原田 康夫
    Department of Otorhinolaryngology, School of Medicine, Hiroshima University
  • 平川 勝洋
    Department of Otorhinolaryngology, School of Medicine, Hiroshima University
  • 竹林 脩文
    Department of Otorhinolaryngology, Hiroshima Prefectural Hospital
  • 小林 優子
    Department of Otorhinolaryngology, Hiroshima Mitsubishi Hospital
  • 関谷 透
    Department of Otorhinolaryngology, School of Medicine, Yamaguchi University
  • 緒方 道彦
    Department of Otorhinolaryngology, School of Medicine, Yamaguchi University
  • 緒方 洋一
    Department of Otorhinolaryngology, School of Medicine, Yamaguchi University
  • 増田 光家
    Department of Otorhinolaryngology, Ube-Kousan Central Hospital
  • 守谷 啓司
    Department of Otorhinolaryngology, Nagato General Hospital
  • 奥園 達也
    Department of Otorhinolaryngology, Shimonoseki National Hospital
  • 奥園 美子
    Department of Otorhinolaryngology, Shimonoseki National Hospital
  • 森満 保
    Department of Otorhinolaryngology, Miyazaki Medical College
  • 松浦 宏司
    Department of Otorhinolaryngology, Miyazaki Medical College
  • 大山 勝
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 松崎 勉
    Department of Otolaryngology, School of Medicine, Kagoshima University
  • 内薗 明裕
    Department of Otorhinolaryngology, Kagoshima Prefectural Hokusatsu Hospital
  • 渡辺 荘郁
    Department of Otorhinolaryngology, Kagoshima Prefectural Hokusatsu Hospital
  • 昇 卓夫
    Department of Otorhinolaryngology, Imakiire General Hospital
  • 宮崎 康博
    Department of Otorhinolaryngology, Imakiire General Hospital
  • 鰺坂 孝二
    Department of Otorhinolaryngology, Satsuma-gun Ishikai Hospital
  • 岩淵 康雄
    Department of Otorhinolaryngology, Kokubu Central Hospital
  • 茂木 五郎
    Department of Otorhinolaryngology, Medical College of Oita
  • 川内 秀之
    Department of Otorhinolaryngology, Medical College of Oita
  • 分藤 準一
    Department of Otorhinolaryngology, Medical College of Oita
  • 吉村 弘之
    Department of Otorhinolaryngology, Oita Prefectural Hospital
  • 金田 規嗣
    Department of Otorhinolaryngology, Saiseikai Shimonoseki General Hospital
  • 高田 順子
    Department of Otorhinolaryngology, Oita Red Cross Hospital
  • 中島 光好
    Department of Pharmacology, Hamamatsu University School of Medicine

書誌事項

タイトル別名
  • A dose-finding study of nasal Fosfomycin (FOM) for the treatment of sinusitis

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抄録

慢性副鼻腔炎急性増悪症に対する鼻科用FOMの臨床用量を検討する目的で, 3%, 5%鼻科用FOMを用い, FOM錠を対照薬とした3群間比較試験を実施し, 有効性, 安全性ならびに有用性を検討し以下の成績を得た.<BR>有効率は, 3%群85%, 5%群76%, 錠剤群57%であり, 3%群と5%群の両薬剤群間に有意差は認められなかつた. 3%群と錠剤群の間には有意差が認められたが, 5%群と錠剤群の間に有意差は認められなかつた. 細菌学的効果あるいはX線所見判定には各群間に有意差は認められなかつた. 副作用発現率は, 3%群2%, 5%群5%, 錠剤群31%で, ネブライザー群と経口群の間には有意差が認められた. 臨床検査値異常は, 錠剤群においてのみ5例認められた.<BR>以上の成績より, FOMネブライザー療法は, 内服療法よりも有用性は高く, 鼻科用 FOMの臨床用量は3%が妥当と考えられた.

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