Monophosphate as Eminent Ligand to Bind Ce(IV)/EDTA Complex for Site-selective DNA Hydrolysis

DOI PDF 被引用文献3件 参考文献13件
  • Wen Chen
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Tomoyuki Igawa
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Jun Sumaoka
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Makoto Komiyama
    Research Center for Advanced Science and Technology, The University of Tokyo

抄録

<jats:title>Abstract</jats:title> <jats:p>By the use of oligonucleotides bearing a terminal monophosphate, 10-base gap was formed in substrate DNA and the monophosphates were placed at the edge of gap. Upon the treatment of these systems with Ce(IV)/EDTA complex, the gap-site was selectively hydrolyzed. The monophosphates remarkably promoted both the selectivity and the efficiency of scission.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 33 (3), 300-301, 2004-02-14

    Oxford University Press (OUP)

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