Monophosphate as Eminent Ligand to Bind Ce(IV)/EDTA Complex for Site-selective DNA Hydrolysis

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Author(s)

    • Chen Wen
    • Research Center for Advanced Science and Technology, The University of Tokyo
    • Igawa Tomoyuki
    • Research Center for Advanced Science and Technology, The University of Tokyo
    • Sumaoka Jun
    • Research Center for Advanced Science and Technology, The University of Tokyo
    • Komiyama Makoto
    • Research Center for Advanced Science and Technology, The University of Tokyo

Abstract

By the use of oligonucleotides bearing a terminal monophosphate, 10-base gap was formed in substrate DNA and the monophosphates were placed at the edge of gap. Upon the treatment of these systems with Ce(IV)/EDTA complex, the gap-site was selectively hydrolyzed. The monophosphates remarkably promoted both the selectivity and the efficiency of scission.

Journal

  • Chemistry Letters

    Chemistry Letters 33(3), 300-301, 2004

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130004423394
  • Text Lang
    ENG
  • ISSN
    0366-7022
  • Data Source
    J-STAGE 
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