End-tether Structure of DNA Alters Electron-transfer Pathway of Redox-labeled Oligo-DNA Duplex at Electrode Surface

• Yasuhiro Mie

  Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

• Naoshi Kojima

  Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

• Keiko Kowata

  Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

• Yasuo Komatsu

  Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

Abstract

We prepared Nile Blue (NB)-modified 17-mer DNA duplexes with thiol/disulfide end tethers for immobilization onto gold electrodes to understand the effect of the tether structure of DNA on its electron-transfer (ET) reactions. The longer thiol tether allowed electron transfer between the NB and the electrode through the DNA duplex, whereas the direct ET pathway became predominant in the shorter disulfide tether. Importantly, the insertion of a spacer chain into the disulfide tether changed the direct ET pathway to a through-DNA pathway.

Journal

• Chemistry Letters

  Chemistry Letters 41 (1), 62-64, 2011-12-24

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360002219111704704
• NII Article ID: 130004426305
• DOI: 10.1246/cl.2012.62
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/41/1/62/55636468/cl.2012.62.pdf
• Data Source:
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  • CiNii Articles
  • KAKEN