Structural Insights for Design of Inhibitors against RISC Function

DOI PDF 参考文献21件
  • Asako Yamayoshi
    Department of Biomolecular Engineering, Kyoto Institute of Technology
  • Yukiko Yamada
    Department of Biomolecular Engineering, Kyoto Institute of Technology
  • Akio Kobori
    Department of Biomolecular Engineering, Kyoto Institute of Technology
  • Akira Murakami
    Department of Biomolecular Engineering, Kyoto Institute of Technology

抄録

<jats:title>Abstract</jats:title> <jats:p>For functional inhibition of RNA-induced silencing complex (RISC), we examined inhibitors called “twist-silencing oligonucleotides (TSO)” containing a linker moiety at the center position of oligonucleotides targeting guide strands in RISC. We found that TSO enhanced the inhibitory effects against RISC function. The concept described in this study may be promising and applicable to regulate small RNA functions.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 41 (12), 1684-1685, 2012-12

    Oxford University Press (OUP)

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