Mitochondria-specific Oxygen Probe Based on Iridium Complexes Bearing Triphenylphosphonium Cation

• Murase Tokiko

  Department of Chemistry and Chemical Biology, Gunma University

• Yoshihara Toshitada

  Department of Chemistry and Chemical Biology, Gunma University

• Tobita Seiji

  Department of Chemistry and Chemical Biology, Gunma University

Abstract

Organelle-selective oxygen probe BTP-Mito was designed and synthesized to selectively target mitochondria. BTP-Mito, which is an iridium complex bearing a triphenylphosphonium cation, exhibited selective mitochondria localization in HeLa cells. The phosphorescence of BTP-Mito was significantly quenched by molecular oxygen in living cells, demonstrating that BTP-Mito can be used as mitochondria-specific oxygen sensor.

Journal

• Chemistry Letters

  Chemistry Letters 41 (3), 262-263, 2012

  The Chemical Society of Japan

Keywords

• General Chemistry

Details

• CRID: 1390001204589471488
• NII Article ID: 130004426512
• DOI: 10.1246/cl.2012.262
• COI: 1:CAS:528:DC%2BC38XkvVKqtbg%3D
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/41/3/262/55638393/cl.2012.262.pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed