Enhancement of Endothelial Function Inhibits Left Atrial Thrombi Development in an Animal Model of Spontaneous Left Atrial Thrombosis

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  • Mawatari Kazuaki
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Yoshioka Emiko
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Toda Satomi
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Yasui Sonoko
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Therapeutic Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Furukawa Hiroko
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Shimohata Takaaki
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Ohnishi Takamasa
    Department of Nutrition Management, Faculty of Health Science, Hyogo University
  • Morishima Masaki
    Department of Cardiovascular Sciences, Oita University School of Medicine
  • Harada Nagakatsu
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Takahashi Akira
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Sakaue Hiroshi
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
  • Nakaya Yutaka
    Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School

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Abstract

Background:Left atrial (LA) thrombosis is an important cause of systemic embolization. The SPORTS rat model of LA thrombi (Spontaneously-Running Tokushima-Shikoku), which have a unique characteristic of high voluntary wheel running, was previously established. The aim of the present study was to investigate how SPORTS rats develop LA thrombi.Methods and Results:Nitric oxide (NO) produced from cardiovascular endothelial cells plays an important protective role in the local regulation of blood flow, vascular tone, and platelet aggregation. No evidence of atrial fibrillation or hypercoagulability in SPORTS rats regardless of age was found; however, SPORTS rats demonstrated endothelial dysfunction and a decrease of NO production from a young age. In addition, endothelial NO synthase activity was significantly decreased in the LA and thoracic aorta endothelia of SPORTS rats. While voluntary wheel running was able to intermittently increase NO levels, running did not statistically decrease the incidence of LA thrombi at autopsy. However, L-arginine treatment significantly increased NO production and provided protection from the development of LA thrombi in SPORTS rats.Conclusions:They present study results indicate that NO has an important role in the development of LA thrombus, and endothelia pathways could provide new targets of therapy to prevent LA thrombosis. (Circ J 2014; 78: 1980–1988)

Journal

  • Circulation Journal

    Circulation Journal 78 (8), 1980-1988, 2014

    The Japanese Circulation Society

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