Experimental Joint Immobilization and Remobilization in the Rats
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- Kojima Satoshi
- Department of Physical Therapy, Faculty of Health Sciences, Kinjo University: 1200 Kasama-machi, Hakusan-city, Ishikawa 924-8511, Japan Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Japan
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- Hoso Masahiro
- Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Japan
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- Watanabe Masanori
- Department of Physical Therapy, Faculty of Rehabilitation Sciences, Nagoya Gakuin University, Japan
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- Matsuzaki Taro
- Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Japan
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- Hibino Itaru
- Department of Physical Therapy, Faculty of Rehabilitation Sciences, Nagoya Gakuin University, Japan
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- Sasaki Kentaro
- Department of Physical Therapy, Faculty of Health Sciences, Kinjo University: 1200 Kasama-machi, Hakusan-city, Ishikawa 924-8511, Japan
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Abstract
[Purpose] The purpose of our study was to clarify temporal effects on restrictions to range of motion and the histopathological changes of joint components after joint immobilization in a rat knee-contracture model. [Subjects] Fifty-four male Wistar rats were randomly divided into two groups: a fixation group, and a control group. [Methods] In the fixation group, unilateral knee joints were immobilized at full flexion using a plaster cast for 4 weeks. At four weeks the animals were randomly divided into six subgroups, corresponding to the time of examination after cast removal: 0, 4, 8, 16, 24, and 32 weeks. For comparison, control group animals of corresponding age were also examined. [Results] Although movement restrictions of the knee joint had completely recovered 6 weeks after the cast removal, cartilage and synovial membrane structures did not completely recover. [Conclusion] These findings have not previously been reported, and as they form an addition to the fundamental scientific foundations of physical therapy, further research must examine these findings from a variety of perspectives.
Journal
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- Journal of Physical Therapy Science
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Journal of Physical Therapy Science 26 (6), 865-871, 2014
The Society of Physical Therapy Science
