Tumor Protein p53 Gene Polymorphism and Developmental Competence of Embryos Derived from in Vitro Fertilization in Old-aged and Long-term Infertile Japanese Black Cows

DOI JASI Web Site 27 References
  • Yuzawa Tomoko
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
  • Fukui Emiko
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
  • Matsumoto Hiromichi
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
  • Kawada Tomohiro
    Tochigi Prefecture Livestock Experiment Station
  • Kawanobe Akio
    Tochigi Prefecture Dairy Experimental Institute
  • Niira Kazutaka
    Tochigi Prefecture Dairy Experimental Institute
  • Ochi Masanori
    Ochi Yume Clinic Nagoya
  • Yoshizawa Midori
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University

Bibliographic Information

Other Title
  • Tumor protein p53遺伝子分析された長期不受胎高齢ウシの体外受精成績

Search this article

Abstract

The present study analyzed tumor protein p53 gene (TP53) polymorphism as a factor in uterine implantation and establishment of pregnancy in four old-aged Japanese Black cows with long-term infertility. They had G allele or A allele in exon 6 of the gene. Oocytes were collected from these females using ovum pick up (OPU) and fertilized in vitro. Only some of the oocytes from individuals having G allele had developmental competence to the blastocyst stage, while no oocytes having the A allele had the competence to develop to the blastocyst stage. In conclusion, we suggest that a cause of long-term infertility in old-aged Japanese Black cows may be a polymorphism of TP53 affecting the competence of embryonic development.<br>

Journal

References(27)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top