Association of the GNAS1 Gene Variant with Hypertension Is Dependent on Alcohol Consumption.

• CHEN Yusen

  Department of Geriatric Medicine, School of Medicine, Ehime University

• NAKURA Jun

  Department of Geriatric Medicine, School of Medicine, Ehime University

• JIN Jing-ji

  Department of Geriatric Medicine, School of Medicine, Ehime University

• WU Zhihong

  Department of Geriatric Medicine, School of Medicine, Ehime University

• YAMAMOTO Miyuki

  Department of Geriatric Medicine, School of Medicine, Ehime University

• ABE Michiko

  Department of Geriatric Medicine, School of Medicine, Ehime University

• TABARA Yasuharu

  Department of Geriatric Medicine, School of Medicine, Ehime University

• YAMAMOTO Yoshikuni

  Department of Geriatric Medicine, School of Medicine, Ehime University

• IGASE Michiya

  Department of Geriatric Medicine, School of Medicine, Ehime University

• BO Xiao

  Department of Neurology, Xiang Ya School of Medicine, Central South University

• KOHARA Katsuhiko

  Department of Geriatric Medicine, School of Medicine, Ehime University

• MIKI Tetsuro

  Department of Geriatric Medicine, School of Medicine, Ehime University

抄録

The β-adrenoceptor (β-AR)-stimulatory guanine nucleotide-binding (Gs) protein system has been shown to play important roles in the cardiovascular system. The gene encoding the α-subunit of Gs proteins (GNAS1) is a candidate genetic determinant for hypertension. Because alcohol consumption is known to affect blood pressure partly through the β-AR-Gs protein system, we examined the possible interaction between GNAS1 T393C polymorphism and drinking status in the association with hypertension in the present study. As a result, a non-significant but reasonable trend supporting the presence of an interaction was shown (p =0.076). In line with this trend, the T393C polymorphism significantly interacted with drinking status in the association with systolic blood pressure (p =0.028). Moreover, supporting the presence of an interaction, T allele carriers consistently had a higher probability of hypertension, higher systolic blood pressure, and higher diastolic blood pressure than CC homozygotes in non-drinkers and light drinkers. In contrast, CC homozygotes consistently had a higher probability of hypertension, higher systolic blood pressure, and higher diastolic blood pressure than T allele carriers in moderate to heavy drinkers. The present study also showed a significant interaction between the T393C polymorphism and drinking status in the association with pulse pressure (p =0.026), reflected by a significant association between the T393C polymorphism and pulse pressure in moderate to heavy drinkers (p =0.026). These findings may be helpful in conducting further molecular and biological studies on the relationship among the effects of alcohol, the β-AR-Gs protein system, and hypertension. (Hypertens Res 2003; 26: 439-444)

収録刊行物

• Hypertension Research

  Hypertension Research 26 (6), 439-444, 2003

  日本高血圧学会

キーワード

• <B>guanine nucleotide-binding proteins</B>
• <B>β-adrenoceptor</B>
• <B>hypertension</B>
• <B>polymorphism</B>
• <B>alcohol</B>

詳細情報

• CRID: 1390001204719235840
• NII論文ID: 130004437060
• NII論文ID: 50000867408
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.26.439
• COI: 1:CAS:528:DC%2BD3sXntVWhtb0%3D
• ISSN: 13484214
• ISSN: 09169636
• PubMed: 12862199
• Web Site: https://search.jamas.or.jp/link/ui/2003309116
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可