Littermate Influence on Infant Growth in Mice: Comparison of SJL/J and ICR as Cotransferred Carrier Embryos

Access this Article

Search this Article

Author(s)

    • JINNO-OUE Atsushi
    • Bioresource Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
    • HATA Hidekazu
    • Bioresource Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan

Abstract

In mice, a minimum number of healthy embryos is required to trigger and maintain pregnancy. Therefore, when recovering mouse embryos from a limited litter, one useful technique is to transfer carrier ICR embryos along with the embryos of interest, a technique referred to as cotransfer. In this study, we examined suitable mouse strains for cotransfer with C57BL/6J (B6) embryos in regards to the maintenance of pregnancy, number of pups born, intrauterine growth, and postnatal growth. Because the coat color of B6 is black, we compared two white coat-colored strains, SJL/J and ICR. Cotransfer of SJL/J and ICR embryos had similar effects on maintenance of pregnancy, number of pups born, and intrauterine growth. However, the postnatal growth of B6 mouse pups cotransferred and grown with SJL/J pups was better than for B6 mouse pups cotransferred and grown with ICR pups, suggesting competition among littermates. These results demonstrate that cotransfer of SJL/J embryos will be useful not only as carrier embryos with B6-background embryos but also as a model system to examine littermate competition.

Journal

  • Proceedings of The Japanese Society of Animal Models for Human Diseases

    Proceedings of The Japanese Society of Animal Models for Human Diseases 63(4), 375-381, 2014

    Japanese Association for Laboratory Animal Science

Codes

  • NII Article ID (NAID)
    130004438747
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    EN
  • ISSN
    1341-1357
  • NDL Article ID
    025857793
  • NDL Call No.
    Z54-H752
  • Data Source
    NDL  J-STAGE 
Page Top