Pore-forming Compounds as Signal Transduction Elements for Highly Sensitive Biosensing

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  • SUGAWARA Masao
    Department of Chemistry, College of Humanities and Sciences, Nihon University
  • SHOJI Atsushi
    School of Pharmacy, Tokyo University of Pharmacy and Life Science
  • SAKAMOTO Misato
    Department of Chemistry, College of Humanities and Sciences, Nihon University

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Pore-forming compounds are attracting much attention due to the signal transduction ability for the development of highly sensitive biosensing. In this review, we describe an overview of the recent advances made by our group in the design of molecular sensing interfaces of spherical and planar lipid bilayers and natural bilayers. The potential uses of pore-forming compounds, such as gramicidin and MCM-41, in lipid bilayers and natural glutamate receptor channels in biomembrane are presented.

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  • Analytical Sciences

    Analytical Sciences 30 (1), 119-128, 2014

    社団法人 日本分析化学会

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