Long-term Follow-up of Patients with Multiple Endocrine Neoplasia Type 1

• SAKURAI Akihiro

  Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine Department of Preventive Medicine, Shinshu University School of Medicine

• KATAI Miyuki

  Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine

• YAMASHITA Koh

  Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine

• MORI Jun-ichiro

  Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine

• FUKUSHIMA Yoshimitsu

  Department of Preventive Medicine, Shinshu University School of Medicine

• HASHIZUME Kiyoshi

  Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine

抄録

Whether early surgical treatment of non-functioning pancreas islet cell tumor (NFPT) provides a favorable quality of life and life expectancy in patients with multiple endocrine neoplasia type 1 (MEN1) remains controversial. We analyzed the long-term clinical courses and surgical outcomes of 14 Japanese patients with MEN1-associated NFPTs. NFPTs smaller than 20 mm in diameter did not show any apparent growth over a long monitoring period. Furthermore, these small NFPTs did not metastasize to regional lymph nodes or the liver. On the other hand, the development of additional NFPTs or metastasis was found in five of six patients with large (35 mm or larger) NFPTs. Among the seven patients who underwent a partial pancreatectomy, six patients developed impaired glucose tolerance or diabetes. The accumulation of more prospective data is needed to clarify the optimal surgical indications for patients with NFPTs, especially among the Japanese population, which has a relatively low insulin secretion potency compared with non-Hispanic white and African-American populations.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 54 (2), 295-302, 2007

  一般社団法人 日本内分泌学会

キーワード

• MEN1
• Tumor growth
• Surgical indication
• Pancreatectomy
• Diabetes

詳細情報

• CRID: 1390001206297419264
• NII論文ID: 10019478820
• NII論文ID: 130004443295
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k06-147
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/54/2/54_2_295/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008000198
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可