Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men

• Shiiya Tomomi

  Faculty of Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan

• Ueno Hiroaki

  Faculty of Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan

• Toshinai Koji

  Faculty of Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan

• Kawagoe Takashi

  Faculty of Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan

• Naito Seiko

  Department of Food and Nutrition, Junshin Junior College, Fukuoka, Japan

• Tobina Takuro

  Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, Fukuoka, Japan

• Nishida Yuichiro

  Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan

• Shindo Munehiro

  Department of Food and Nutrition, Junshin Junior College, Fukuoka, Japan

• Kangawa Kenji

  National Cardiovascular Center Research Institute, Osaka, Japan

• Tanaka Hiroaki

  Department of Food and Nutrition, Junshin Junior College, Fukuoka, Japan

• Nakazato Masamitsu

  Faculty of Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan

抄録

Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and growth hormone (GH) secretion via interaction with the GH secretagogue receptor. Ghrelin molecules are present in two major endogenous forms, an acylated form (ghrelin) and a des-acylated form (des-acyl ghrelin). Recent studies indicated that aerobic exercise did not change plasma total ghrelin levels, however, dynamics of circulating ghrelin and des-acyl ghrelin during aerobic exercise remains unclear. The purpose of this study is to examine the effects of moderate intensity exercise on plasma ghrelin and des-acyl ghrelin concentrations, and to investigate the relationship between ghrelin molecules and other hormonal and metabolic parameters during exercise. Nine healthy males (25.2 ± 0.5 years) exercised for 60 min at 50% of their maximal oxygen consumptions. We measured the plasma concentrations of ghrelin, des-acyl ghrelin, GH, norepinephrine (NE), epinephrine (E), dopamine (DA), insulin, and glucose. Plasma ghrelin level significantly decreased during exercise, whereas plasma des-acyl ghrelin and total ghrelin levels did not change. Plasma NE, E, DA and GH levels were significantly increased during exercise. Plasma insulin level significantly decreased during exercise, and plasma glucose levels remained steady during exercise. NE, E, DA, and GH were correlated negatively with plasma ghrelin levels. These findings suggest that acute moderate exercise may suppress ghrelin release from the stomach, decrease ghrelin O-acyltransferase activity, and/or activate ghrelin utilization in peripheral tissues and that exercise-induced ghrelin suppression may be mediated by activated adrenergic system.

収録刊行物

• Endocrine Journal

  Endocrine Journal 58 (5), 335-342, 2011

  一般社団法人 日本内分泌学会

キーワード

• Ghrelin
• Des-acyl ghrelin
• Growth hormone
• Adrenergic system
• Exercise

詳細情報

• CRID: 1390282681275480832
• NII論文ID: 10029588473
• NII論文ID: 130004443692
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k11e-021
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/58/5/58_K11E-021/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012137255
• 本文言語コード: en
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