Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients

この論文にアクセスする

この論文をさがす

著者

    • Tanaka Yuko
    • Department of Breast and Endocrine Surgery, University of Tsukuba, Tsukuba 305-8575, Japan
    • Hataya Yuji
    • Department of Endocrinology, Kyoto City Hospital, Kyoto 604-8845, Japan
    • Kato Taiya
    • Department of Internal Medicine, Aichi Koseiren Toyota Kosei Hospital, Toyota 470-0396, Japan
    • Kamide Kei
    • Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan
    • Ikeda Yukihiro
    • Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
    • Okada Yosuke
    • The First Department of Internal Medicine, School of Medicine University of Occupational and Environmental Health, Japan, Kitakyushu, 807-8555, Japan
    • Adachi Masahiro
    • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • Yanase Toshihiko
    • Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan
    • Takahashi Hideto
    • Biostatistics Office, Tsukuba Critical Path Research and Education Integrated Leading (CREIL) Center, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • Yokoyama Chie
    • Division of Laboratory, University of Tsukuba Hospital, Tsukuba 305-8575, Japan
    • Arai Yusuke
    • Division of Laboratory, University of Tsukuba Hospital, Tsukuba 305-8575, Japan
    • Isobe Kazumasa
    • Department of Laboratory Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • Hashimoto Koichi
    • Tsukuba Critical Path Research and Education Integrated Leading Center (CREIL), Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • Shimano Hitoshi
    • Department of Endocrinology and Metabolism, University of Tsukuba, Tsukuba 305-8575, Japan
    • Hara Hisato
    • Department of Breast and Endocrine Surgery, University of Tsukuba, Tsukuba 305-8575, Japan
    • Kawakami Yasushi
    • Department of Laboratory Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • Takekoshi Kazuhiro
    • Faculty of Medicine, Division of Sports Science, University of Tsukuba, Tsukuba 305-8575, Japan
    • Ma Enbo
    • Biostatistics Office, Tsukuba Critical Path Research and Education Integrated Leading (CREIL) Center, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    • Imai Tsuneo
    • Division of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, Nagakute, Aichi 480-1195, Japan
    • Kikumori Toyone
    • Department of Breast and Endocrine Surgery, Nagoya University Hospital, Nagoya 466-8550, Japan
    • Matsuda Tadashi
    • Department of Urology and Andrology, Kansai Medical University, Hirakata, 573-1191, Japan
    • Maeda Yuji
    • Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan
    • Sakurai Akihiro
    • Department of Medical Genetics, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
    • Midorikawa Sanae
    • Department of Radiation Health Management, Fukushima Medical University, Fukushima 960-1295, Japan

抄録

Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNs) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanephrines (uMNs) were 0.980 <i>VS</i> 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 <i>VS</i> 0.894 for sensitivity, and 0.973 <i>VS</i> 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNs) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports.

収録刊行物

  • Endocr J

    Endocr J 61(7), 667-673, 2014

    一般社団法人 日本内分泌学会

各種コード

  • NII論文ID(NAID)
    130004443981
  • 本文言語コード
    ENG
  • ISSN
    0918-8959
  • データ提供元
    J-STAGE 
ページトップへ