The combination of IMT and stiffness parameter β is highly associated with concurrent coronary artery disease in type 2 diabetes

• Lee Eiko

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Emoto Masanori

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Teramura Megumi

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Tsuchikura Shoko

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Ueno Hiroki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Shinohara Kayo

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Morioka Tomoaki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Mori Katsuhito

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Koyama Hidenori

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Shoji Tetsuo

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Okuno Yasuhisa

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Inaba Masaaki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Nishizawa Yoshiki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

書誌事項

タイトル別名

• The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

抄録

Aims: The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter β (ST) and IMT with concurrent CAD.<BR>Methods: IMT and ST were measured by ultrasound in 439 nondiabetic subjects as a control and 1528 type 2 diabetic subjects (T2DM) with or without CAD in a cross-sectional study.<BR>Results: Both IMT and ST significantly increased with age and group category, in the order of control, T2DM without CAD, and T2DM with CAD (p<0.001). The area under the curve on ROC analysis of ST for concurrent CAD was comparable to that for IMT. On multivariate logistic regression analysis, High IMT (≥1.30 mm) and High stiffness (≥20.0) had significant odds ratios for concurrent CAD (2.205, p<0.001 and 1.548, p<0.05, respectively). The group with High IMT and High Stiffness exhibited a stronger multivariate odds ratio (3.115, p=0.0001).<BR>Conclusions: ST and IMT are associated with CAD and exhibited significant odds ratios for CAD. Our findings suggest that the combination of IMT and ST is a useful marker of atherosclerosis.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 16 (1), 33-39, 2009

  一般社団法人 日本動脈硬化学会

キーワード

• Carotid atherosclerosis
• Type 2 diabetes
• Coronary artery disease
• Ultrasound

詳細情報

• CRID: 1390282679410207872
• NII論文ID: 130004444254
• DOI: 10.5551/jat.e605
• ISSN: 18803873
• ISSN: 13403478
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可