Smoking Status is Associated with Serum High Molecular Adiponectin Levels in Community-Dwelling Japanese Men

• Kawamoto Ryuichi

  Department of Community Medicine, Ehime University Graduate School of Medicine. Department of Internal Medicine, Seiyo Municipal Nomura Hospital.

• Tabara Yasuharu

  Department of Geriatric Medicine, Ehime University Graduate School of Medicine.

• Kohara Katsuhiko

  Department of Geriatric Medicine, Ehime University Graduate School of Medicine.

• Miki Tetsuro

  Department of Geriatric Medicine, Ehime University Graduate School of Medicine.

• Ohtsuka Nobuyuki

  Department of Internal Medicine, Seiyo Municipal Nomura Hospital.

• Kusunoki Tomo

  Department of Community Medicine, Ehime University Graduate School of Medicine. Department of Internal Medicine, Seiyo Municipal Nomura Hospital.

• Abe Masanori

  Department of Community Medicine, Ehime University Graduate School of Medicine.

抄録

Aim: Serum high molecular weight (HMW) adiponectin improves insulin sensitivity, and a decreased level has been reported as a risk factor for the development of diabetes and coronary heart disease. This association may be further confounded by smoking, which is involved in the development of insulin resistance. The aim of this study was to determine whether smoking status is associated with serum HMW adiponectin levels in community-dwelling males.<BR>Methods: The cross-sectional study was carried out in 2002. Study participants without a clinical history of diabetes (724 men aged 60±14 (mean±standard deviation) (range, 20-89) years) were randomly recruited from a single community at an annual physical examination. They were classified into never-smokers, ex-smokers, light-smokers (<30 pack·year), and heavy-smokers (≥30 pack·year).<BR>Results: Mean serum HMW adiponectin levels were significantly lower in the current smokers than in the never- and ex-smokers but showed no significant difference between the light and heavy-smokers. Multiple linear regression analyses revealed that smoking status was significantly associated with HMW adiponectin levels, as were age, BMI, alcohol consumption, triglycerides, and high-density lipoprotein cholesterol. Multivariate-adjusted mean serum HMW adiponectin levels were lowest in the heavy-smokers, and significantly decreased in heavy-smokers compared with never-smokers and ex-smokers of an age ≥60 years, BMI≥22kg/m², alcohol consumption ≥22.9g of ethanol/day, and HOMA-IR ≥1.6.<BR>Conclusion: Smoking status is associated with serum HMW adiponectin levels in community-dwelling Japanese men.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 17 (4), 423-430, 2010

  一般社団法人 日本動脈硬化学会

キーワード

• Adiponectin
• Smoking
• Body mass index
• Risk factor
• Insulin resistance

詳細情報

• CRID: 1390001204431010048
• NII論文ID: 130004444438
• NII論文ID: 50007681816
• DOI: 10.5551/jat.3681
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://search.jamas.or.jp/link/ui/2011089963
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可