Serum Fetuin-A is an Independent Marker of Insulin Resistance in Japanese Men

DOI 2 Citations 33 References
  • Ishibashi Ayako
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University.
  • Ikeda Yukio
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University.
  • Ohguro Takashi
    Department of Health Examination, Kochi Red Cross Hospital.
  • Kumon Yoshitaka
    Department of Laboratory Medicine, Kochi Medical School, Kochi University
  • Yamanaka Shigeo
    Department of Laboratory Medicine, Kochi Medical School, Kochi University
  • Takata Hiroshi
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University.
  • Inoue Mari
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University.
  • Suehiro Tadashi
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University.
  • Terada Yoshio
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University.

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Abstract

Aim: Fetuin-A, also known as alpha2-Heremans Schmid glycoprotein, is an abundant plasma protein synthesized predominantly in the liver. Fetuin-A inhibits insulin receptor autophosphorylation, which is mediated by its intrinsic tyrosine kinase activity. In this study, we examined the association between the serum fetuin-A level and insulin resistance in Japanese men.<BR>Methods: We recruited 300 unrelated Japanese men without known chronic diseases, such as diabetes mellitus, or a history of regular drug use, and who underwent health examinations. From a 75-g oral glucose tolerance test, the study population included 194 individuals with normal glucose tolerance, 91 with impaired glucose tolerance and/or impaired fasting glucose, and 15 with diabetes mellitus. Serum fetuin-A concentrations were measured using an ELISA kit.<BR>Results: Serum fetuin-A concentrations were positively correlated with fasting insulin levels (r=0.269, p<0.001), HOMA-IR (r=0.274, p<0.001) and LDL-cholesterol (r=0.172, p<0.01), and nega-tively correlated with HDL-cholesterol concentrations (r=-0.191, p<0.001). Fetuin-A concentra-tions were also positively correlated with serum leptin (r=0.150, p<0.01) and negatively with adi-ponectin concentrations (r=-0.208, p<0.001). Stepwise regression analyses confirmed that the fetuin-A concentration was independently associated with the fasting insulin level and HOMA-IR, as were body mass index, triglyceride, LDL-cholesterol, leptin and adiponectin concentrations.<BR>Conclusion: Our data suggest that increased serum fetuin-A levels constitute an independent marker of insulin resistance and an atherogenic lipid profile in Japanese men.

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