Plaque Regression Determined by Intravascular Ultrasound Predicts Long-Term Outcomes of Patients with Acute Coronary Syndrome

• Dohi Tomotaka

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Miyauchi Katsumi

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Okazaki Shinya

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Yokoyama Takayuki

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Yanagisawa Naotake

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Tamura Hiroshi

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Kojima Takahiko

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Yokoyama Ken

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Kurata Takeshi

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

• Daida Hiroyuki

  Department of Cardiovascular Medicine, Juntendo University School of Medicine.

抄録

Aim: The usefulness of drugs to treat plaque regression is assessed by intravascular ultrasound (IVUS); however, the impact of plaque regression on clinical outcomes in patients with acute coronary syndrome (ACS) has not been established; therefore, we investigated the relationship between coronary plaque regression and long-term clinical outcomes.<BR>Methods: We analyzed data from 86 patients who underwent percutaneous coronary intervention (PCI) and who were assessed in detail at baseline and at 6 months of follow-up by measuring proximal non-culprit sites of PCI lesions using volumetric IVUS. Patients were divided according to changes in plaque volume over 6 months into one group with plaque regression (n =55; 64.0%) and another with progression (n =31; 36.0%). They were followed up observationally for a mean of 1,736 days.<BR>Results: Baseline characteristics at the time of ACS were similar between the groups. The probability of event-free survival was significantly higher in the regression group than in the progression group as estimated by the Kaplan-Meier method (Log-rank test, p =0.032). Furthermore, the Cox hazards model revealed the relative contribution of plaque regression as a predictor of cardiovascular events (hazard ratio: 0.26; 95% CI, 0.07 to 0.83; p =0.023).<BR>Conclusions: Plaque regression determined by volumetric IVUS over a period of 6 months was associated with a lower rate of cardiovascular events among patients with ACS. This study also demonstrated that plaque regression could be a surrogate marker of future cardiovascular events.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 18 (3), 231-239, 2011

  一般社団法人 日本動脈硬化学会

キーワード

• Plaque regression
• Prognosis
• Acute coronary syndrome
• Atherosclerosis

詳細情報

• CRID: 1390282679410041344
• NII論文ID: 130004444503
• NII論文ID: 50007960647
• DOI: 10.5551/jat.6551
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://search.jamas.or.jp/link/ui/2012013359
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可