Patients with CD36 Deficiency Are Associated with Enhanced Atherosclerotic Cardiovascular Diseases
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- Yuasa-Kawase Miyako
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Masuda Daisaku
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Yamashita Taiji
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Kawase Ryota
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Nakaoka Hajime
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Inagaki Miwako
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Nakatani Kazuhiro
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Tsubakio-Yamamoto Kazumi
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Ohama Tohru
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine. Health Care Center, Osaka University.
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- Matsuyama Akifumi
- Department of Somatic Stem Cell Therapy, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation.
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- Nishida Makoto
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine. Health Care Center, Osaka University.
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- Ishigami Masato
- Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine.
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- Kawamoto Toshiharu
- Kure Heart Center, National Hospital Organization Kure Medical Center.
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- Komuro Issei
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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- Yamashita Shizuya
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients.<BR>Methods: By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of 123I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n =319) and healthy subjects (n =1,239) were underwent.<BR>Results: The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p <0.0001).<BR>Conclusion: The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 19 (3), 263-275, 2012
一般社団法人 日本動脈硬化学会
