Defining Patients at Extremely High Risk for Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia

Access this Article

Author(s)

    • Sugisawa Takako
    • Division of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center.
    • Harada-Shiba Mariko
    • Division of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center.|Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute.
    • Makino Hisashi
    • Division of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center.
    • Watanabe Makoto
    • Department of Preventive Cardiology, National Cerebral and Cardiovascular Center.
    • Kishimoto Ichiro
    • Division of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center.
    • Miyamoto Yoshihiro
    • Department of Preventive Cardiology, National Cerebral and Cardiovascular Center.
    • Iwamoto Noriyuki
    • Division of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center.
    • Yokoyama Shinji
    • Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University.

Abstract

Aim: Heterozygous patients with familial hypercholesterolemia (FH) are known to be associated with a high risk of coronary artery disease (CAD), which is a major determinant of their clinical outcome. The prognosis of heterozygous FH patients substantially varies, being dependent on the level of their CAD risk, and their therapeutic regimen should be individualized. We assessed critical levels of LDL-cholesterol (LDL-C) and Achilles tendon thickness (ATT) to identify heterozygous FH patients at “very high” risk for CAD.<BR>Methods: One hundred and nine heterozygous FH patients who had no history of CAD and had had their plasma lipid profile and ATT assessed before treatment were followed up until their first CAD event or 31 December 2010. Multivariable logistic regression models were used to analyze the correlation of LDL-C and/or ATT levels with the risk of developing CAD.<BR>Results: During the follow-up period, 21 of the 109 patients had a CAD event, diagnosed by coronary angiogram. Individuals in the highest tertile of LDL-C had a CAD risk 8.29-fold higher than those in the lowest tertile. Individuals in the highest tertile of the ATT group had a 7.82-fold higher CAD risk than those in the lowest tertile. Those who had either LDL-C ≥ 260 mg/dL or ATT ≥ 14.5 had a 23.94-fold higher CAD risk than those with LDL-C < 260 mg/dL and ATT <14.5 mm.<BR>Conclusions: In heterozygous FH patients, LDL-C 260 mg/dL or higher and/or ATT 14.5 mm or thicker are useful markers for extracting patients at “very high” risk for CAD.

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 19(4), 369-375, 2012

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130004444603
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
Page Top