High-Density Lipoprotein Levels Have Markedly Increased Over the Past Twenty Years in Japan
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- Yokoyama Shinji
- Nutritional Health Science Research Center, Chubu University
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- Ueshima Hirotsugu
- Health Science, Shiga University of Medical Science
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- Miida Takashi
- Clinical Laboratory Medicine, Juntendo University Graduate school of Medicine
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- Nakamura Masakazu
- Lipid Reference Laboratory at National Cerebral and Cardiovascular Center under The Cholesterol Reference Method Laboratory Network of CDC
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- Takata Koki
- Preventive Medicine Center, Chugoku Rosai Hospital
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- Fukukawa Tatsuyuki
- Quality Assurance Department, SRL Inc.
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- Goto Takaaki
- Clinical Chemistry Laboratory, Nagoya City University Hospital
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- Harada-Shiba Mariko
- Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
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- Sano Michitaka
- Clinical Chemistry of National Cerebral and Cardiovascular Center Hospital
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- Kato Kiminori
- Niigata Association of Occupational Health
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- Matsuda Kazuhiro
- Niigata Association of Occupational Health
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Abstract
Aim: The high-density lipoprotein cholesterol(HDL-C) level is a major negative risk factor for atherosclerotic diseases dependent on various lifestyle parameters. Changes in the lifestyle of Japanese individuals over the past several decades is believed to have increased their total cholesterol levels and the incidence of cardiovascular disease in Japan. It is therefore important to assess the long-term trends in the HDL-C levels with respect to public health in the community.<br> Methods: In this study, accumulated data for the serum/plasma HDL-C levels published in cohort studies and obtained during health checkup programs in Japan were analyzed with respect to timedependent changes.<br> Results: The levels of HDL-C have continuously and significantly increased over the past 20 years by 12-15% according to the National Health and Nutrition Study, other cohort studies and commercially available data. On the other hand, the non-HDL-cholesterol levels demonstrated no changes or only a slight decrease during the same period. This finding is consistent with several sets of data obtained from health checkup programs. The commercially measured levels of serum apoA-I, an independent parameter of serum HDL, also showed a similar long-term increase, supporting the above findings.<br> Conclusion: We concluded that the serum/plasma HDL concentrations in Japanese individuals, selectively, have increased continuously and significantly over the past 20 years or more. The reasons for this phenomenon and the consequent public health outcomes have yet to be investigated.
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 21 (2), 151-160, 2014
Japan Atherosclerosis Society
