The High Molecular Weight Adiponectin Level is Associated with the Atherogenic Lipoprotein Profiles in Healthy Japanese Males

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Author(s)

    • Miyazaki Tetsuro
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • Hiki Makoto
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • Shimada Kazunori
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • Kume Atsumi
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • Kiyanagi Takashi
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • Ohmura Hirotoshi
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine
    • Daida Hiroyuki
    • Department of Cardiovascular Medicine, Juntendo University School of Medicine

Abstract

<b><i>Aim</i></b>: Circulating adiponectin comprises high, medium and low molecular weight (HMW, MMW, and LMW) forms. Decreased adiponectin levels have been demonstrated to correlate with the atherogenic lipoprotein profile in patients with metabolic syndrome(MS). However, the associations of these isoforms with the atherogenic lipoprotein profiles in the healthy population remain unclear.<br><b><i>Methods</i></b>: Apparently healthy male subjects were divided into non-MS(<i>n</i>=132) and MS(<i>n</i>=63) groups. We measured the total, HMW, MMW and LMW adiponectin levels by ELISA, and determined the detailed lipoprotein profiles by high-performance liquid chromatography.<br><b><i>Results</i></b>: The total and HMW adiponectin levels in the MS group were significantly lower than those in the non-MS group(3.8±1.9 vs. 4.9±2.4<i>μ</i>g/mL, <i>p</i><0.001 and 1.6±1.2 vs. 2.5±1.9<i>μ</i>g/mL, <i>p</i><0.001, respectively), whereas the MMW and LMW levels did not differ significantly between the groups. The total and HMW adiponectin levels correlated with the atherogenic lipoprotein profiles, including the following: 1) increased cholesterol levels in the small LDL subclasses; 2) decreased cholesterol levels in the larger HDL subclasses; 3) increased triglycerides(TGs) in almost all VLDL and LDL subclasses and 4) decreased TGs in the large HDL and increased TGs in the small HDL subclasses. In addition, a multivariate analysis demonstrated that the HMW adiponectin level was an independent predictor of the small LDL and HDL levels(<i>p</i>=0.02 for both).<br><b><i>Conclusions</i></b>: The HMW, but not MMW or LMW, adiponectin levels are associated with the typical atherogenic lipoprotein profiles, independent of MS components. Measurement of the HMW adiponectin levels could be useful for identifying the atherogenicity in apparently healthy males.

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 21(7), 672-679, 2014

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130004444791
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
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