<i>Garcinia vilersiana</i> bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells

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Author(s)

    • Shinkai Yasuhiro Shinkai Yasuhiro
    • Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba|Master’s Program in Environmental Sciences, Graduate School of Life and Environmental Sciences, University of Tsukuba
    • Quynh Nguyen Thi
    • Department of Plant Cell Technology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam
    • Kanaho Yasunori
    • Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • Kumagai Yoshito
    • Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba|Master’s Program in Environmental Sciences, Graduate School of Life and Environmental Sciences, University of Tsukuba

Abstract

<i>Garcinia vilersiana</i> is a traditional medicinal plant in Vietnam. The petroleum ether extract of stem bark of <i>Garcinia vilersiana</i> (GVE) was prepared to evaluate its potential to activate Nrf2, a transcription factor of antioxidant and detoxifying enzymes. Exposure of mouse macrophage RAW264.7 cells to GVE (0.625-2.5 µg/ml) resulted in a significant activation of Nrf2, as evaluated by nuclear accumulation of this transcription factor, and increased antioxidant response element (ARE) binding activity in a time- and concentration-dependent manner. As a result, GVE caused ARE-dependent up-regulation of heme oxygenase-1 (HO-1) in the cells. These results suggest that GVE contains components that have the ability to activate the Nrf2/ARE/HO-1 signaling pathway, leading to cellular protection.

Journal

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 38(6), 875-878, 2013

    The Japanese Society of Toxicology

Codes

  • NII Article ID (NAID)
    130004447090
  • NII NACSIS-CAT ID (NCID)
    AN00002808
  • Text Lang
    ENG
  • ISSN
    0388-1350
  • NDL Article ID
    025811601
  • NDL Call No.
    Z19-1022
  • Data Source
    NDL  J-STAGE 
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