<i>Garcinia vilersiana</i> bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells
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<i>Garcinia vilersiana</i> is a traditional medicinal plant in Vietnam. The petroleum ether extract of stem bark of <i>Garcinia vilersiana</i> (GVE) was prepared to evaluate its potential to activate Nrf2, a transcription factor of antioxidant and detoxifying enzymes. Exposure of mouse macrophage RAW264.7 cells to GVE (0.625-2.5 µg/ml) resulted in a significant activation of Nrf2, as evaluated by nuclear accumulation of this transcription factor, and increased antioxidant response element (ARE) binding activity in a time- and concentration-dependent manner. As a result, GVE caused ARE-dependent up-regulation of heme oxygenase-1 (HO-1) in the cells. These results suggest that GVE contains components that have the ability to activate the Nrf2/ARE/HO-1 signaling pathway, leading to cellular protection.
- The Journal of Toxicological Sciences
The Journal of Toxicological Sciences 38(6), 875-878, 2013
The Japanese Society of Toxicology